Replenishment of vitamin D status: theoretical and practical considerations
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In recent years, there have been a very large number of scientific publications concerning various aspects of vitamin D, ranging from physiologic to therapeutic studies. However, despite the multiple discoveries made in this fast-growing scientific research area, numerous issues still remain unresolved [1, 2]. Examples include, though are not limited to, the definition of hypovitaminosis D (this term is used to cover cases of both insufficiency and deficiency), i.e. 20 vs 30 ng/mL; the relationship between 25(OH)D and parathyroid hormone (PTH) (linear vs non-linear and related point of inflection) [3, 4, 5]; the referent that should be considered (total vs free determination) ; and the utility of screening for hypovitaminosis vs universal supplementation .
However, one of the most heatedly debated issues is the question of what comprises appropriate treatment. Indeed, irrespective of the threshold adopted, there is uncertainty regarding the specific vitamin and the dose that...
KeywordsVitamin D Prevention Treatment Toxicity
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Conflict of interest
The authors declare that they have no conflict of interest.
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