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Pretibial myxedema in a euthyroid patient

  • Panagiotis Anagnostis
  • Aikaterini Artzouchaltzi
  • Alexandra Grekou
  • Stavroula A. Paschou
  • Spyridon Gerou
  • Vasilios Tzalokostas
Case Report


Pretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves’ disease (GD), usually during the hyperthyroid state, coexisting with orbitopathy. We describe a rare case of a biopsy-proven PM in a euthyroid patient, without history of GD or Hashimoto’s thyroiditis. Assessment of commonly reported thyroid autoantibodies, such as thyroid peroxidase and thyroglobulin autoantibodies, thyroid stimulating immunoglobulins and thyroid binding inhibitory immunoglobulins, was negative. Resolution of skin pathology was achieved after topical application of corticosteroids and was sustained 1 year later.


Pretibial myxedema Thyroid 


Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to disclose.


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Copyright information

© Hellenic Endocrine Society 2018

Authors and Affiliations

  • Panagiotis Anagnostis
    • 1
  • Aikaterini Artzouchaltzi
    • 1
  • Alexandra Grekou
    • 2
  • Stavroula A. Paschou
    • 3
  • Spyridon Gerou
    • 4
  • Vasilios Tzalokostas
    • 1
  1. 1.Division of EndocrinologyPolice Medical Center of ThessalonikiThessalonikiGreece
  2. 2.Laboratory of Histopathology “Histodiagnostiki”ThessalonikiGreece
  3. 3.Division of Endocrinology and Diabetes, “Aghia Sophia” Hospital, Medical SchoolNational and Kapodistrian University of AthensAthensGreece
  4. 4.Laboratories “Analysis”ThessalonikiGreece

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