History of induced abortions and frailty in older Greek women: results from the HELIAD study
- 9 Downloads
Women are almost twice as likely as men to develop frailty and early-traumatic experiences related to reproduction may have a role to play. The purpose of this study was to investigate the association between a history of induced abortions and risk of frailty.
1062 women aged ≥ 65 years from the HELIAD study were included in the present cross-sectional study. Frailty was assessed by frailty index and Fried definitions. The history of abortion and of other reproductive experiences (age onset of menstruation, age of menopause, number of offspring, and number of miscarriages) was obtained by all participants. Logistic and linear regression analyses were performed to examine whether the number of abortions was related to frailty.
When frailty was defined with frailty index, women with 1 or 2 abortions had 1.7 higher risk of frailty compared to women with no history of abortions, while those with more than 3 abortions had more than a twofold higher risk of frailty. Two supplementary analyses excluding women with surgical operations’ history and women with dementia revealed similar results. When frailty was defined with Fried definition, the analysis was marginally significant when abortion was inserted as a categorical variable. Women with more than 3 abortions showed 2.4 higher risk of frailty compared to women with no history of abortion.
The number of induced abortions was associated with moderate higher odds of frailty, when frailty was defined according to frailty index. A similar trend was revealed in the model with Fried definition after trichotomization of abortions.
KeywordsFrailty Abortions Women Greece
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
The study protocol was approved by the University of Thessaly and the National and Kapodistrian University of Athens Ethics Committees.
All participants gave their informed consent prior to study participation.
- 1.Kinsella K, Phillips DR (2005) Global aging: the challenge of success. Popul Bull 60:1–44Google Scholar
- 2.Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol Ser A Biol Sci Med Sci 56:M146–M157. https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/56.3.M146
- 6.Barmpouti A (2015) Eugenics, demography and family planning in Greece, 1950–1980: the activities of the Hellenic Eugenics Society. PhD. Oxford Brookes UniversityGoogle Scholar
- 13.Fountoulakis KN, Tsolaki M, Iacovides A, Yesavage J, O’Hara R, Kazis A et al (1999) The validation of the short form of the Geriatric Depression Scale (GDS) in Greece. Aging (Milano) 11:367–372Google Scholar
- 17.Stenholm S, Sallinen J, Koster A, Rantanen T, Sainio P, Heliövaara M et al (2011) Association between obesity history and hand grip strength in older adults-exploring the roles of inflammation and insulin resistance as mediating factors. J Gerontol A Biol Sci. Med Sci [Internet] 66:341–8. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3041473&tool=pmcentrez&rendertype=abstract
- 18.Roubenoff R (2004) Sarcopenic obesity: the confluence of two epidemics. Obes Res 887–8Google Scholar
- 19.Ortolá R, García-Esquinas E, León-Muñoz LM, Guallar-Castillón P, Valencia-Martín JL, Galán I et al (2016) Patterns of alcohol consumption and risk of frailty in community-dwelling older adults. J Gerontol Ser A Biol Sci Med Sci [Internet] 71:251–258. https://doi.org/10.1093/gerona/glv125 CrossRefGoogle Scholar
- 22.Bountziouka V, Bathrellou E, Giotopoulou A, Katsagoni C, Bonou M, Vallianou N et al (2012) Development, repeatability and validity regarding energy and macronutrient intake of a semi-quantitative food frequency questionnaire: methodological considerations. Nutr Metab Cardiovasc Dis 22:659–667CrossRefPubMedGoogle Scholar
- 24.Thorp JMJ, Hartmann KE, Shadigian E (2003) Long-term physical and psychological health consequences of induced abortion: review of the evidence. Obstet Gynecol Surv [Internet] 58:67–79. http://ovidsp.ovid.com/ovidweb.cgi?T=JS%7B&%7DPAGE=reference%7B&%7DD=med4%7B&%7DNEWS=N%7B&%7DAN=12544786
- 26.Fine-Davis M (2017) Psychological effects of abortion on women: a review of the literature Item type Report. http://hdl.handle.net/10147/305322
- 33.Barile-Fabris LA, Pérez-Cristobal M, Merlos-López RJ, Xibillé-Friedman D (2016) Frailty syndrome in patients with rheumatoid arthritis. Rev Med Inst Mex Seguro Soc [Internet] 54 Suppl 2:S210–S215. http://www.ncbi.nlm.nih.gov/pubmed/27561027
- 35.Barzilay JI, Blaum C, Moore T, Xue QL, Hirsch CH, Walston JD et al (2007) Insulin resistance and inflammation as precursors of frailty: the cardiovascular health study. Arch Intern Med [Internet] 167:635–641. http://archinte.jamanetwork.com/article.aspx?articleid=412120
- 40.Katz PP, Andrews J, Yelin EH YJ (2016) Is frailty a relevant concept in systemic lupus erythematosus (SLE)? Arthritis Rheumatol [Internet] (suppl 10):68. http://acrabstracts.org/abstract/is-frailty-a-relevant-concept-in-systemic-lupus-erythematosus-sle/