Multi-step continuous flow synthesis of fluconazole
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The development of a flow chemistry approach to the anti-fungal fluconazole is described. A continuous, two-reactor, three-step synthesis of fluconazole from 2-chloro-2′,4′-difluoroacetophenone was achieved with no intermediate purification. The synthesis has been successfully demonstrated on a Vapourtec commercial flow chemistry system.
KeywordsFluconazole Corey-Chaykovsky epoxidation 1,2,4-triazole Friedel-crafts acylation Vapourtec
This research was developed with funding from the Defense Advanced Research Projects Agency (DARPA, W911NF-16-C-0051). The views, opinions, and/or findings expressed are those of the author(s) and should not be interpreted as representing the official views or policies of the Department of Defense or the U.S. Government.
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