Advertisement

Lasers in Dental Science

, Volume 3, Issue 3, pp 147–153 | Cite as

Photobiomodulation therapy in the treatment of periodontal disease: a literature review

  • Fuad AlaijahEmail author
  • Asmaa Morsi
  • Riman Nasher
  • Norbert Gutknecht
Review Article
  • 15 Downloads

Abstract

Objectives

Many studies in the literature address the effect of photobiomodulation therapy in the management of pathologies related to periodontal tissue. Due to the lack of standardized information and the absence of a consensus, this review presents the recent evidence on the effect of photobiomodulation (PBM) on proliferation of fibroblast cells and osteoblast cells in periodontal tissues.

Materials and methods

The literature and original research articles were used to investigate the effect of photobiomodulation therapy in periodontal diseases. Online MEDLINE/PubMed and Google scholar were used. Access dates were between 2010 and 2017. The research was confined to English-language literature. The literature search retrieved references on proliferation of fibroblast cells and osteoblast cells. Each topic is individually addressed in this review.

Results

In total, 13 14 relevant photobiomodulation articles were included in the review, comprising work completed on a variety of cell types and places. Although results consistently demonstrated the potential of laser irradiation to affect cellular proliferation in a wavelength- and dosage-dependent manner, the relevance of other key irradiation parameters, such as irradiance, to such effects remained unclear.

Conclusion

The literature review showed several positive results of the PBM on proliferation of fibroblast cells and osteoblast cells in periodontal tissues.

Keywords

Photobiomodulation (PBM) Periodontal disease Wound healing Bone healing Fibroblast cells Osteoblast cells 

Abbreviations

aPDT

antimicrobial photodynamic therapy

PDLFs

human periodontal ligament fibroblasts

PBM

photobiomodulation

PDGF

platelet-derived growth factor

SRP

scaling and root planing

NO

nitric oxide

ROS

reactive oxygen species

ATP

adenosine triphosphate

Λ

wavelength

Hz

frequency

J/cm2

energy density

hPDLCs

human periodontal ligament cell

HGF

human gingival fibroblasts

bFGF

basic fibroblast growth factor

IGF

insulin-like growth factor

IGFBP3

receptor of IGF-1

BMP

bone morphogenetic protein

Notes

References

  1. 1.
    Saini R, Marawar PP, Shete S, Saini S (2009) Periodontitis, a true infection. J Global Infect Dis 1(2):149–150.  https://doi.org/10.4103/0974-777X.56251 CrossRefGoogle Scholar
  2. 2.
    Palomo, L., Palomo, J. M., & Bissada, N. F. (2008). Salient periodontal issues for the modern biologic orthodontist. In Seminars in Orthodontics (Vol. 14, No. 4, pp. 229–245). WB Saunders.  https://doi.org/10.1053/j.sodo.2008.07.002
  3. 3.
    Highfield, J. (2009). Diagnosis and classification of periodontal disease.Australian dental journal, 54, S11-S26.  https://doi.org/10.1111/j.1834-7819.2009.01140.x
  4. 4.
    Marques MM, de Cara SPHM, Abe GL, Pedroni ACF, Diniz IMA, Moreira MS (2017) Effects of photobiomodulation therapy in dentoalveolar-derived mesenchymal stem cells: a review of literature. Lasers Dent Sci 1(1):1–7.  https://doi.org/10.1007/s41547-017-0002-3 CrossRefGoogle Scholar
  5. 5.
    Huang YY, Sharma SK, Carroll J, Hamblin MR (2011) Biphasic dose response in low level light therapy–an update. Dose-Response 9(4):dose-response.  https://doi.org/10.2203/dose-response.11-009.Hamblin CrossRefGoogle Scholar
  6. 6.
    Pesevska S, Nakova M, Gjorgoski I, Angelov N, Ivanovski K, Nares S, Andreana S (2012) Effect of laser on TNF-alpha expression in inflamed human gingival tissue. Lasers Med Sci 27(2):377–381.  https://doi.org/10.1007/s10103-011-0898-x CrossRefGoogle Scholar
  7. 7.
    Renno AC, McDonnell PA, Parizotto NA, Laakso EL (2007) The effects of laser irradiation on osteoblast and osteosarcoma cell proliferation and differentiation in vitro. Photomed Laser Surg 25:275–280.  https://doi.org/10.1089/pho.2007.2055 CrossRefGoogle Scholar
  8. 8.
    Kiyosaki T, Mitsui N, Suzuki N, Shimizu N (2010) Low-level laser therapy stimulates mineralization via increased Runx2 expression and ERK phosphorylation in osteoblasts. Photomed Laser Surg 28(Suppl 1):S167–S172.  https://doi.org/10.1089/pho.2009.2693 CrossRefGoogle Scholar
  9. 9.
    Huertas RM, Luna-Bertos ED, Ramos-Torrecillas J, Leyva FM, Ruiz C, García-Martínez O (2014) Effect and clinical implications of the low-energy diode laser on bone cell proliferation. Biol Res Nurs 16(2):191–196.  https://doi.org/10.1177/1099800413482695 CrossRefGoogle Scholar
  10. 10.
    Mamalis A, Siegel D, Jagdeo J (2016) Visible red light emitting diode photobiomodulation for skin fibrosis: key molecular pathways. Curr Dermatol Rep 5(2):121–128.  https://doi.org/10.1007/s13671-016-0141-x CrossRefGoogle Scholar
  11. 11.
    Huang YY, Chen ACH, Hamblin M (2009) Low-level laser therapy: an emerging clinical paradigm. SPIE Newsroom 9:1–3.  https://doi.org/10.1117/2.1200906.1669 Google Scholar
  12. 12.
    Choi EJ, Yim JY, Koo KT, Seol YJ, Lee YM, Ku Y, Rhyu IC, Chung CP, Kim TI (2010) Biological effects of a semiconductor diode laser on human periodontal ligament fibroblasts. J Periodontal Implant Sci 40(3):105–110.  https://doi.org/10.5051/jpis.2010.40.3.105 CrossRefGoogle Scholar
  13. 13.
    Aykol G, Baser U, Maden I, Kazak Z, Onan U, Tanrikulu-Kucuk S, Ademoglu E, Issever H, Yalcin F (2011) The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment. J Periodontol 82(3):481–488.  https://doi.org/10.1902/jop.2010.100195 CrossRefGoogle Scholar
  14. 14.
    Hakki SS, Bozkurt SB (2012) Effects of different setting of diode laser on the mRNA expression of growth factors and type I collagen of human gingival fibroblasts. Lasers Med Sci 27(2):325–331.  https://doi.org/10.1007/s10103-010-0879-5 CrossRefGoogle Scholar
  15. 15.
    Schartinger VH, Galvan O, Riechelmann H, Dudás J (2012) Differential responses of fibroblasts, non-neoplastic epithelial cells, and oral carcinoma cells to low-level laser therapy. Support Care Cancer 20(3):523–529.  https://doi.org/10.1007/s00520-011-1113-0 CrossRefGoogle Scholar
  16. 16.
    Basso FG, Pansani TN, Turrioni APS, Bagnato VS, Hebling J, de Souza Costa CA (2012) In vitro wound healing improvement by low-level laser therapy application in cultured gingival fibroblasts. Int J Dent 2012.  https://doi.org/10.1155/2012/719452
  17. 17.
    Wu JY, Chen CH, Yeh LY, Yeh ML, Ting CC, Wang YH (2013) Low-power laser irradiation promotes the proliferation and osteogenic differentiation of human periodontal ligament cells via cyclic adenosine monophosphate. Int J Oral Sci 5(2):85–91.  https://doi.org/10.1038/ijos.2013.38 CrossRefGoogle Scholar
  18. 18.
    Obradović R, Kesić L, Mihailović D, Antić S, Jovanović G, Petrović A, Peševska S (2013) A histological evaluation of a low-level laser therapy as an adjunct to periodontal therapy in patients with diabetes mellitus. Lasers Med Sci 28(1):19–24.  https://doi.org/10.1007/s10103-012-1058-7 CrossRefGoogle Scholar
  19. 19.
    Forouzanfar A (2014) The effects of low-level laser therapy on the expression of collagen type I gene and proliferation of human gingival fibroblasts (Hgf3-Pi 53): in vitro study. Int J Pediatr 2(2.3):65–65.  https://doi.org/10.22038/IJP.2014.2728 Google Scholar
  20. 20.
    Petri AD, Teixeira LN, Crippa GE, Beloti MM, Oliveira PTD, Rosa AL (2010) Effects of low-level laser therapy on human osteoblastic cells grown on titanium. Braz Dent J 21(6):491–498.  https://doi.org/10.1590/S0103-64402010000600003 CrossRefGoogle Scholar
  21. 21.
    Makhlouf M, Dahaba MM, Tunér J, Eissa SA, Harhash TAH (2012) Effect of adjunctive low level laser therapy (LLLT) on nonsurgical treatment of chronic periodontitis. Photomed Laser Surg 30(3):160–166.  https://doi.org/10.1089/pho.2011.3069 CrossRefGoogle Scholar
  22. 22.
    Medina-Huertas R, Manzano-Moreno FJ, De Luna-Bertos E, Ramos-Torrecillas J, García-Martínez O, Ruiz C (2014) The effects of low-level diode laser irradiation on differentiation, antigenic profile, and phagocytic capacity of osteoblast-like cells (MG-63). Lasers Med Sci 29(4):1479–1484.  https://doi.org/10.1007/s10103-014-1557-9 Google Scholar
  23. 23.
    Abolfazli N, Sadighi SM, Sadighi SM, Rikhtegaran S (2012) Effect of low-level laser therapy and autogenous bone graft on bone regeneration in the treatment of two wall and three wall intrabony periodontal defects: a clinical study. 8(Number 4 (42)):6-14.  https://doi.org/10.1111/j.1834-7819.2009.01140.x
  24. 24.
    Parker S (2007) Verifiable CPD paper: low-level laser use in dentistry. Br Dent J 202(3):131–138.  https://doi.org/10.1038/bdj.2007.75 CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Fuad Alaijah
    • 1
    Email author
  • Asmaa Morsi
    • 2
  • Riman Nasher
    • 3
  • Norbert Gutknecht
    • 4
  1. 1.Faculty of DentistryAl Asmarya UniversityZlitenLibya
  2. 2.AALZ Aachen Dental Laser Center at RWTHAachenGermany
  3. 3.Department of Conservative DentistryRWTH Aachen University HospitalAachenGermany
  4. 4.Medical FacultyRWTH Aachen UniversityAachenGermany

Personalised recommendations