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Normal CSF orexin levels in the patients with hypersomnolence following HPV vaccination

  • Aya Imanishi
  • Takashi KanbayashiEmail author
  • Yohei Sagawa
  • Takaki Taniguchi
  • Akari Usumoto
  • Kotaro Yuge
  • Nozomu Kotorii
  • Tomomi Kinoshita
  • Toshiaki Hirai
  • Yuki Omori
  • Kazuhisa Yoshizawa
  • Tetsuo Shimizu
Short Paper
  • 13 Downloads

Abstract

Public concern has been growing over severe adverse events caused by human papillomavirus (HPV) vaccination. Some patients also exhibited sleep disorders. We investigated their symptoms, clinical examinations and cerebrospinal fluid orexin (hypocretin) levels. The subjects were 6 patients with hypersomnolence after HPV vaccination. Since all of them had normal orexin levels, hypersomnolence was not caused by orexin deficiency. Although each case did not meet the diagnostic criteria of narcolepsy type 2 and idiopathic hypersomnia adequately, one case had frequent multiple SOREMPs and the other had shortened sleep latency. They might be affected with symptoms of hypersomnolence disorders after their vaccination.

Keywords

Human papillomavirus vaccination Hypersomnolence Orexin Hypocretin 

Notes

Author contributions

Conception and design of the study: AI, TK, YS, TS. Acquisition and analysis of data: YT, AU, KY, NK, TK, TH, YO, JT. Drafting the manuscript or figures: AI, TK, YS.

Compliance with ethical standards

Conflict of interest

There is no conflict of interest in this study.

References

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Copyright information

© Japanese Society of Sleep Research 2019

Authors and Affiliations

  • Aya Imanishi
    • 1
  • Takashi Kanbayashi
    • 1
    • 2
    Email author
  • Yohei Sagawa
    • 1
  • Takaki Taniguchi
    • 3
  • Akari Usumoto
    • 3
  • Kotaro Yuge
    • 4
  • Nozomu Kotorii
    • 5
  • Tomomi Kinoshita
    • 6
  • Toshiaki Hirai
    • 7
  • Yuki Omori
    • 1
  • Kazuhisa Yoshizawa
    • 1
  • Tetsuo Shimizu
    • 1
    • 2
  1. 1.Department of NeuropsychiatryAkita University School of MedicineAkitaJapan
  2. 2.International Institute for Integrative Sleep Medicine, Tsukuba UniversityTsukubaJapan
  3. 3.Department of Neurology and GeriatricsKagoshima University School of MedicineKagoshimaJapan
  4. 4.Department of PediatricsKurume University School of MedicineKurumeJapan
  5. 5.Department of NeuropsychiatryKurume University School of MedicineKurumeJapan
  6. 6.Department of Medicine (Neurology and Rheumatology)Sinshu University School of MedicineMatsumoto cityJapan
  7. 7.Department of NeurologyTeikyo University School of Medicine, Mizonokuchi HospitalKawasakiJapan

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