Normal CSF orexin levels in the patients with hypersomnolence following HPV vaccination
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Public concern has been growing over severe adverse events caused by human papillomavirus (HPV) vaccination. Some patients also exhibited sleep disorders. We investigated their symptoms, clinical examinations and cerebrospinal fluid orexin (hypocretin) levels. The subjects were 6 patients with hypersomnolence after HPV vaccination. Since all of them had normal orexin levels, hypersomnolence was not caused by orexin deficiency. Although each case did not meet the diagnostic criteria of narcolepsy type 2 and idiopathic hypersomnia adequately, one case had frequent multiple SOREMPs and the other had shortened sleep latency. They might be affected with symptoms of hypersomnolence disorders after their vaccination.
KeywordsHuman papillomavirus vaccination Hypersomnolence Orexin Hypocretin
Conception and design of the study: AI, TK, YS, TS. Acquisition and analysis of data: YT, AU, KY, NK, TK, TH, YO, JT. Drafting the manuscript or figures: AI, TK, YS.
Compliance with ethical standards
Conflict of interest
There is no conflict of interest in this study.
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