Sleep and Biological Rhythms

, Volume 17, Issue 1, pp 149–153 | Cite as

Sub-analysis of the prevalence of locomotive syndrome and its relationship with health-related quality of life in patients with obstructive sleep apnea syndrome as classified by age and sex

  • Hiroaki KataokaEmail author
  • Nobuyuki Miyatake
  • Hirohisa Ichikawa
  • Yukako Arakawa
  • Yoshihiro Mori
Original Article


The purpose of this study was to investigate the prevalence of locomotive syndrome (LS) in patients with obstructive sleep apnea syndrome (OSAS), and to compare the health-related quality of life (HRQOL) among patients with and without LS as classified by age and sex. A total of 1173 patients with OSAS (1013 males and 160 females) who were treated with continuous positive airway pressure (CPAP) therapy were enrolled in this cross-sectional study. Male participants were divided into 6 groups (30–39 years, 40–49 years, 50–59 years, 60–69 years, 70–79 years, and 80–89 years) and female participants were divided into 5 groups (40–49 years, 50–59 years, 60–69 years, 70–79 years, and 80–89 years). LS was evaluated using a “loco-check” established by the Japanese Orthopedic Association. HRQOL was evaluated using the EuroQol 5-dimensional questionnaire (EQ-5D). The prevalence of LS among the different age and sex groups was 19.6–79.4% in males and 27.0–95.5% in females and increased with age. In males aged 30–39 and 70–79 years, and in females aged 50–59 years, the EQ-5D scores were significantly lower in OSAS patients with LS than in OSAS patients without LS, even after adjusting for confounding factors. In OSAS patients, LS was closely linked to HRQOL. Preventing and improving the outcomes of LS would be beneficial for improving the HRQOL in OSAS patients.


Obstructive sleep apnea syndrome Locomotive syndrome Prevalence rate Health-related quality of life 



This research was supported in part by research grants form Nankaiikueikai, Japan.

Compliance with ethical standards

Conflict of interest

The authors declare that there were no means of financial support or relationships that could pose a conflict of interest.

Ethics approval

The research ethics committee of KKR Takamatsu Hospital approved this cross-sectional study (Ethics ID E111).


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Copyright information

© Japanese Society of Sleep Research 2018

Authors and Affiliations

  • Hiroaki Kataoka
    • 1
    Email author
  • Nobuyuki Miyatake
    • 2
  • Hirohisa Ichikawa
    • 3
  • Yukako Arakawa
    • 3
  • Yoshihiro Mori
    • 3
  1. 1.Rehabilitation CenterKKR Takamatsu HospitalTakamatsuJapan
  2. 2.Department of Hygiene, Faculty of MedicineKagawa UniversityTakamatsuJapan
  3. 3.Sleep and Respiratory Disease CenterKKR Takamatsu HospitalTakamatsuJapan

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