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Topics in Current Chemistry

, 377:34 | Cite as

State-of-the-Art and Prospects of Biomolecules: Incorporation in Functional Metal–Organic Frameworks

  • Wenjie Duan
  • Zhengfeng Zhao
  • Hongde An
  • Zhenjie Zhang
  • Peng Cheng
  • Yao ChenEmail author
  • He Huang
Review
Part of the following topical collections:
  1. Metal–Organic Framework: From Design to Applications

Abstract

Given the unique properties of metal–organic frameworks (MOFs) including adjustable porosity, high surface area, and easy modification, they have attracted great attention as excellent solid supports for the incorporation of biomolecules. The formed biomolecules–MOFs composites show promising prospects in various fields such as biocatalysis, drug delivery, and biosensing. This review focuses on the state-of-the-art of biomolecules-incorporation using MOFs. Moreover, the relationship between properties of MOFs and biomolecules-incorporation is also discussed and highlighted. We hope this work will inspire the innovation in this emerging field for highly efficient synthesis of biomolecules–MOFs composites with various properties and advanced applications.

Keywords

Metal–organic frameworks Biomolecules Incorporation Application 

Abbreviations

ABTS

2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)

BSL2

Bacillus subtilis lipase

BSA

Bovine serum albumin

CAL-B

Candida-antarctica-lipase B

Cyt c

Cytochrome c

DBCO

Dibenzylcyclooctyne

DCC

Dicyclohexylcarbodiimide

DNA

Deoxyribonucleic acid

EDC

1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide

FITC

Fluorescein isothiocyanate

GOx

Glucose oxidase

HRP

Horseradish peroxidase

HSA

Human serum albumin

LDH

Lactate dehydrogenase

MBS

Mesoporous benzene silica

Mb

Myoglobin

MOFs

Metal–organic frameworks

MP-11

Microperoxidase-11

NBD

4-Chloro-7-nitrobenzofurazan

OPAA

Organophosphorus acid anhydrolase

OVA

Ovalbumin

PNA

Peptide nucleic acid

PVP

Polyvinylpyrrolidone

RNA

Ribonucleic acid

SDSL-EPR

Site-directed spin labeling in combination with electron paramagnetic resonance

SEH

Soybean epoxide hydrolase

ssDNA

Single-stranded DNA

THB

1,2,3-Trihydroxybenzene

XPS

X-ray photoelectron spectroscopy

Notes

Acknowledgements

The authors acknowledge the financial support from the National Key Research and Development Program of China (2018YFA0901800), National Natural Science Foundation of China (21871153, 31800793).

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.State Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjinPeople’s Republic of China
  2. 2.School of Food Science and Pharmaceutical EngineeringNanjing Normal UniversityNanjingPeople’s Republic of China
  3. 3.College of PharmacyNankai UniversityTianjinPeople’s Republic of China
  4. 4.College of ChemistryNankai UniversityTianjinPeople’s Republic of China

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