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Topics in Current Chemistry

, 377:28 | Cite as

Synthesis and Biological Activities of Chemical Drugs for the Treatment of Rheumatoid Arthritis

  • Shiyang Zhou
  • Huiying Zou
  • Guangying Chen
  • Gangliang HuangEmail author
Review
  • 52 Downloads

Abstract

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the joints, with the main clinical manifestations being chronic, symmetrical, and peripheral multi-joint inflammatory lesions. Drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids (GCs), disease-modifying anti-rheumatic drugs (DMARDs), and biologics play a very important role in the treatment of RA. Of these, the most commonly used are chemical drugs, such as NSAIDs, GCs, and DMARDs. In recent years, a number of new compounds have emerged for the treatment of RA, such as SYK inhibitors, JAK inhibitors, NSAID-CAI drugs, and Syk/PDGFR-α/c-Kit inhibitors. In this review, we summarize the most recently developed anti-RA chemical drugs and discuss the synthesis and biological activities of these various new compounds.

Keywords

Rheumatoid arthritis Chemical drugs Synthesis Biological activities 

Notes

Acknowledgements

The Project was sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (No. 2015-1098). The work was also supported by Chongqing Key Research Project of Basic Science and Frontier Technology (No. cstc2017jcyjBX0012), Foundation Project of Chongqing Normal University (No. 14XYY020), Chongqing General Research Program of Basic Research and Frontier Technology (No. cstc2015jcyjA10054), Chongqing Normal University Postgraduate’s Research and Innovation Project (No. YKC17004), the National Natural Science Foundation (21662012, 41866005), Postgraduate Research and Innovation Project of Hainan Normal University (Hsyx2018-8), and Open Foundation Project of Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education (RDZH2019002), China.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Shiyang Zhou
    • 1
    • 2
  • Huiying Zou
    • 1
    • 2
  • Guangying Chen
    • 1
    • 2
  • Gangliang Huang
    • 3
    Email author
  1. 1.College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikouChina
  2. 2.Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of EducationHainan Normal UniversityHaikouChina
  3. 3.Chongqing Key Laboratory of Green Synthesis and Application, Active Carbohydrate Research InstituteChongqing Normal UniversityChongqingChina

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