Cross-Dehydrogenative Coupling Reactions Between C(sp)–H and X–H (X = N, P, S, Si, Sn) Bonds: An Environmentally Benign Access to Heteroatom-Substituted Alkynes

  • Wanxi PengEmail author
  • Esmail Vessally
  • Sattar Arshadi
  • Aazam Monfared
  • Akram Hosseinian
  • Ladan Edjlali


Form a green and sustainable chemistry point of view, cross-dehydrogenative coupling (or oxidative cross-coupling) reactions have been recognized as environmentally sustainable and atom economical synthetic routes for the construction of new carbon–carbon and carbon–heteroatom bonds, since no pre-functionalization of starting materials is required. In the past few years, the direct coupling of sp-hybridized C–H bonds with heteroatom–H bonds has received much attention because of the importance of heteroatom-substituted alkynes in organic and medicinal chemistry. This review examines the recent developments in cross-dehydrogenative coupling reactions between C(sp)–H and X–H (X = N, P, S, Si, Sn) bonds, with a particular focus on the mechanistic aspects of the reactions.


Cross-dehydrogenative couplings Terminal alkynes Ynamides Alkynyl-phosphonates Alkynyl sulfides Alkynyl silanes Alkynyl stannanes 



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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Wanxi Peng
    • 1
    Email author
  • Esmail Vessally
    • 2
  • Sattar Arshadi
    • 2
  • Aazam Monfared
    • 2
  • Akram Hosseinian
    • 3
  • Ladan Edjlali
    • 4
  1. 1.School of ForestryHenan Agricultural UniversityZhengzhouChina
  2. 2.Department of ChemistryPayame Noor UniversityTehranIran
  3. 3.School of Engineering Science, College of EngineeringUniversity of TehranTehranIran
  4. 4.Department of Chemistry, Tabriz BranchIslamic Azad UniversityTabrizIran

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