Dermatomyositis as a Paraneoplastic Manifestation of Ovarian Cancer: A Case Report and Review of Literature

  • Charu Mahajan
  • Chandrima Ray
  • Ashish SinghalEmail author
  • Bimlesh Thakur
  • Rahat Hadi
  • Pradyuman Singh
Case Report


Dermatomyositis (DM) is a rare autoimmune disease that occurs throughout the world. It is characterized by pathognomonic cutaneous features and symmetrical proximal muscle weakness of striated muscles of limbs, although an amyopathic form of dermatomyositis also exists. The disease is mainly idiopathic but may present as a cutaneous manifestation of cancer. Pathogenesis of DM is poorly understood, but it is believed that it is caused by altered cellular and humoral immunity. Diagnosis is based on a characteristic clinical picture confirmed by biochemistry and biopsy of skin and muscle. Treatment is mainly by steroids, immunosuppressive drugs and management of underlying malignancy. Recurrence of dermatomyositis symptoms is often the first sign of relapse. Prognosis of ovarian cancer in context of dermatomyositis is poor. We hereby report a case of DM who on investigations is diagnosed to have underlying ovarian cancer. She is managed by systemic steroids, chemotherapy and cytoreductive surgery leading to the resolution of disease which again relapsed after 1 year, again preceded by onset of rash and managed by second-line chemotherapy and monoclonal antibody.


Dermatomyositis Steroids Rash Muscle 




Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  • Charu Mahajan
    • 1
  • Chandrima Ray
    • 2
  • Ashish Singhal
    • 2
    Email author
  • Bimlesh Thakur
    • 2
  • Rahat Hadi
    • 3
  • Pradyuman Singh
    • 4
  1. 1.Department of GynecologyLucknowIndia
  2. 2.Department of Surgical OncologyLucknowIndia
  3. 3.Department of Radiation OncologyLucknowIndia
  4. 4.Department of PathologyLucknowIndia

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