Advertisement

Primary Non-Hodgkin’s Lymphoma of Vagina: A Rare Case Report

  • Chauhan RichaEmail author
  • Nishi
  • Trivedi Vinita
  • Verma Pranab Kumar
Case Report
  • 3 Downloads

Abstract

Non-Hodgkin’s lymphoma (NHL) is a malignancy of the lymphoid system, but one-third of NHL can arise from tissues other than lymph nodes, spleen and even sites devoid of lymphoid tissues. These primary extranodal NHLs are commonly found in the gastrointestinal and head and neck region. Primary NHL of vagina is a rare clinical finding with only few case reports and series till date. Because of its rarity and clinical similarities to vaginal carcinoma, biopsy along with a panel of immunohistochemistry markers is required to establish the diagnosis. The staging is usually done by PET–CT scan. By extrapolating the results of chemotherapy and radiation in the nodal lymphomas, these tumors have also been successfully treated with either chemotherapy alone for early and non-bulky disease or chemotherapy with involved field radiation for advanced stage and bulky diseases. Here, we present the case of a 65-year-old lady, who presented with postmenopausal bleeding and was eventually diagnosed to be a case of primary NHL of vagina.

Keywords

Non-Hodgkin’s lymphoma Extranodal Vagina Immunohistochemistry Chemotherapy 

Notes

Compliance with Ethical Standards

Conflict of interest

There is no conflict of interest among authors.

References

  1. 1.
    Mishra P, Das S, Kar R, Jacob SE, Basu D. Primary extranodal non-Hodgkin lymphoma: a 3-year record-based descriptive study from a tertiary care center in Southern India. Indian J Pathol Microbiol. 2015;58(3):296–300.  https://doi.org/10.4103/0377-4929.162834.CrossRefPubMedGoogle Scholar
  2. 2.
    Trenhaile TR, Killackey MA. Primary pelvic non-Hodgkin’s lymphoma. Obstet Gynecol. 2001;97(5 Pt 1):717–20.PubMedGoogle Scholar
  3. 3.
    Vannata B, Zucca E. Primary extranodal B-cell lymphoma: current concepts and treatment strategies. Chin Clin Oncol. 2015;4(1):10.  https://doi.org/10.3978/j.issn.2304-3865.2014.12.01.CrossRefPubMedGoogle Scholar
  4. 4.
    Krol AD, Le Cessie S, Snijder S, Kluin-Nelemans JC, Kluin PM, Noordijk EM. Primary extranodal non-Hodgkin’s lymphoma (NHL): the impact of alternative definitions tested in the Comprehensive Cancer Centre West population-based NHL registry. Ann Oncol. 2003;14(1):131–9.CrossRefGoogle Scholar
  5. 5.
    Cohn DE, Resnick KE, Eaton LA, et al. Non-Hodgkin’s lymphoma mimicking gynecological malignancies of the vagina and cervix: a report of four cases. Int J Gynecol Cancer. 2007;17(1):274–9.CrossRefGoogle Scholar
  6. 6.
    Vang R, Medeiros LJ, Ha CS, Deavers M. Non-Hodgkin’s lymphomas involving the uterus: a clinicopathologic analysis of 26 cases. Mod Pathol. 2000;13(1):19–28.CrossRefGoogle Scholar
  7. 7.
    Guastafierro S, Tedeschi A, Criscuolo C, Celentano M, Cobellis L, Rossiello R, Falcone U. Primary extranodal non-Hodgkin’s lymphoma of the vagina: a case report and a review of the literature. Acta Haematol. 2012;128(1):33–8.  https://doi.org/10.1159/000337336.CrossRefPubMedGoogle Scholar
  8. 8.
    Cheson BD, Fisher RI, Barrington SF, et al. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification. J Clin Oncol. 2014;32(27):3059–68.  https://doi.org/10.1200/JCO.2013.54.8800.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Signorelli M, Maneo A, Cammarota S, Isimbaldi G, Garcia Parra R, Perego P, Maria Pogliani E, Mangioni C. Conservative management in primary genital lymphomas: the role of chemotherapy. Gynecol Oncol. 2007;104(2):416–21 Epub 2006 Oct 16.CrossRefGoogle Scholar
  10. 10.
    Held G, Murawski N, Ziepert M, Fleckenstein J, Pöschel V, Zwick C, Bittenbring J, Hänel M, Wilhelm S, Schubert J, et al. Role of radiotherapy to bulky disease in elderly patients with aggressive B-cell lymphoma. J Clin Oncol. 2014;32(11):1112–8.  https://doi.org/10.1200/JCO.2013.51.4505 Epub 2014 Feb 3.CrossRefPubMedGoogle Scholar

Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  • Chauhan Richa
    • 1
    • 3
    Email author
  • Nishi
    • 2
  • Trivedi Vinita
    • 1
  • Verma Pranab Kumar
    • 2
  1. 1.Department of Radiation OncologyMahavir Cancer SansthanPatnaIndia
  2. 2.Department of PathologyMahavir Cancer SansthanPatnaIndia
  3. 3.PatnaIndia

Personalised recommendations