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Redistribution of Cervix Cancer Patients from FIGO 2009 to FIGO 2018 Staging Following Incorporation of Medical Imaging

  • Kailash NarayanEmail author
  • Ming Yin Lin
  • Srinivas Kondalsamy-Chennakesvan
  • David Bernshaw
  • Amita Maheshwari
  • Neerja Bhatla
Original Article
  • 2 Downloads
Part of the following topical collections:
  1. Controversies to Consensus : Recent advances

Abstract

Objectives

The aim of this study was to quantify the shift in patients from the FIGO 2009 to the FIGO 2018 staging using a prospectively collected dataset where pre-treatment MRI and PET-CT were used. A secondary aim was to explore the distribution of known prognostic factors in both staging schema.

Methods

Prospectively collected dataset of 1047 cervix cancer patients staged with MRI and PET-CT, between 1996 and 2014, were redistributed using FIGO 2018 staging criteria. Standard deviation inter-quartile and contingency tables were used to present the distribution of patients according to FIGO 2009 and FIGO 2018 criteria. Logistic regression was used to evaluate the association of node positivity and nodal size.

Results and Discussion

In total, 853 patients were available for analyses. Based on MRI and PET findings, according to FIGO 2009, the incidence of lymph node metastasis was similar in (1) stages 1b1 and 2a1, (2) 1b, 2a2, 2b and 3a (3) 3b and 4a. Nodal metastases were found in 43% patients who were upstaged from FIGO 2009 to newly created FIGO 2018 stages 3c1 and 3c2. Contribution to stage 3c1 came from 31, 41, 29, 30, 32, 33 and 34% of stages 1b1, 1b2, 2a1, 2a2, 3a and 3b, respectively. FIGO 2009 stages 1b1 and 1b2 contributed 5 and 6%, stages 2a1, 2a2, 2b and 3a contributed 16, 15 and 15% to para-aortic nodes, while stage 3b contributed 24%. These findings will likely influence cervix cancer treatment policies.

Keywords

Cervix cancer FIGO staging Imaging MRI PET 

Notes

Funding

No financial remuneration was recieved by any authors towards writing this manuscript or data collection.

Compliance with ethical standards

Conflict of interest

None of authors have any conflict of interest.

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Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Radiation Oncology, Peter MacCallum Cancer CentreMelbourneAustralia
  2. 2.Department of Obstetrics and GynaecologyUniversity of MelbourneMelbourneAustralia
  3. 3.Rural Clinical SchoolThe University of QueenslandToowoombaAustralia
  4. 4.Department of Gynecologic OncologyTata Memorial CentreMumbaiIndia
  5. 5.Department of Obstetrics and GynecologyAll India Institute of Medical SciencesNew DelhiIndia

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