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Gestational Trophoblastic Disease: Prevalence, Management and Follow-Up at a Tertiary Center in Oman—An 11-Year Study

  • Fatma Al Wahaibi
  • Huda Al Ghaithi
  • Ruqiya AlShamsi
  • Vaidyanathan GowriEmail author
  • Thuria Al Rawahi
Original Article
  • 15 Downloads

Abstract

Objective

The objective of this study is to estimate the prevalence, management and follow-up of gestational trophoblastic disease (GTD) in a tertiary care center, Royal Hospital, in Oman over the last 11 years from January 2007 till December 2017. This study also looked into the reproductive outcome after trophoblastic disease treatment.

Methods

This retrospective, descriptive study was carried out at Royal Hospital from Jan. 2007 to Dec. 2017. All cases with a histopathological report of hydatidiform molar disease were included. Demographic characteristics, clinical presentation physical signs, treatment and follow-up including reproductive outcome and recurrence rate were included.

Results

Two hundred and thirty-six women with GTD were included in the study. Mean maternal age was 35 years, mean gravidity 5 and parity 3. Prevalence of complete mole was 83 cases (35.1%), partial mole 144 cases (61%), choriocarcinoma (0.42%), placental site (0.42%) and invasive mole (1.27%). Thyrotoxicosis, preeclampsia and anemia were 3.8%, 7.2% and 0.8%, respectively. Mean gestational age was 10.57 ± 3.2 weeks at presentation. Persistent disease was observed in 12.3%. About 5% received chemotherapy. Metastasis was reported in 4.7% of cases, 81.8% to the lung. About 38% conceived later.

Conclusion

This study highlights the importance of proper assessment and follow-up of histopathology diagnosis. GTD usually has a good prognosis and reproductive outcome if properly followed up and treated.

Keywords

Gestational trophoblastic disease Molar pregnancy Partial molar pregnancy Metastases Prevalence 

Notes

Funding

None.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Obstetrics and Gynecology Residency Training ProgramOman Medical Specialty BoardMuscatOman
  2. 2.Obstetrics and Gynecology DepartmentRoyal HospitalMuscatOman
  3. 3.Department of HistopathologyRoyal HospitalMuscatOman
  4. 4.Obstetrics and Gynecology Department, College of Medicine and Health SciencesSultan Qaboos UniversityMuscatOman

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