Synchronous Primary Cancer of Cervix and Non-genital Metastatic Tumor of Ovary: A Rare Case Report

  • Aruna ChhikaraEmail author
  • B. S. Johal
  • Swarnlata
Case Report



Synchronous malignancies in the female genital tract are uncommon. We here present the first documented case of a synchronous cervical adenocarcinoma with a non-cervical metastatic ovarian tumor.

Case Report

A 41-year-old woman was admitted with complains of abdominal pain on and off. General physical examination and systemic examination were normal. CT suggested a possibility of complex cystic adnexal masses likely an ovarian tumor. The uterus and cervix appeared unremarkable. A radical abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Based on the histopathological and immunohistochemical findings, a diagnosis of a synchronous metastatic tumor to the ovary (most likely gastrointestinal origin) and primary adenocervical carcinoma was made.


Multiple genital malignancies often present as a diagnostic dilemma. It is essential to differentiate primary malignancies from metastatic disease as there is great variation in overall survival and management. Immunohistochemistry plays a key role when the histomorphological features fail to decipher the origin of malignancy.


Compliance with Ethical Standards

Conflict of interest

Both authors declare that they have no conflict of interest.


  1. 1.
    Tong SY, Lee YS, Park JS, Bae SN, Lee JM, Namkoong SE. Clinical analysis of synchronous primary neoplasm of the female reproductive tract. Eur J Obstet Gynecol Reprod Biol. 2008;136:78.CrossRefGoogle Scholar
  2. 2.
    Srivastava K, Zahra F. Synchronous primary malignancy of ovary and cervix with different histopathology: a rare presentation. Int J Gynecol Obstet. 2009;12(2):4.Google Scholar
  3. 3.
    Katke RD, Gadekar S, Pagare P. A rare case of carcinoma of ovary with carcinoma of cervix. J Case Rep. 2014;4(1):217–20.CrossRefGoogle Scholar
  4. 4.
    Fatima Q, Dubey S, Kapuriya S. Synchronous primary carcinomas of cervix and ovary: a case report. J Dent Med Sci. 2016;15(8):71–5.Google Scholar
  5. 5.
    Nanda S, Malhotra V, Bhugra P, Chauhan M, Kataria S. Hidden synchronous cervical malignancy in a case of ovarian cancer. J Gynecol Surg. 2014;30(4):219–21.CrossRefGoogle Scholar
  6. 6.
    Das P, Kumar N, Gupta SD. Metastatic tumors in ovaries. Indian J Med Paediatr Oncol. 2009;30(1):38–45.Google Scholar
  7. 7.
    Holtz F, Hart WR. Krukenberg tumors of the ovary. A clinicopathologic analysis of 27 cases. Cancer. 1982;50:2438–47.CrossRefGoogle Scholar
  8. 8.
    Renaud MC, Plante M, Roy M. Metastatic gastrointestinal tract cancer presenting as ovarian carcinoma. J Obstet Gynaecol Can. 2003;25(10):819–24.CrossRefGoogle Scholar
  9. 9.
    Xiang L, Kong B. PAX8 is a novel marker for differentiating between various types of tumor, particularly ovarian epithelial carcinomas. Oncol Lett. 2013;5(3):735–8.CrossRefGoogle Scholar
  10. 10.
    Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 2003;27(3):303–10.CrossRefGoogle Scholar

Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Department of Laboratory SciencesJohal Multispeciality HospitalJalandharIndia

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