Excellent Outcome in a Patient with Choriocarcinoma with Spinal Metastasis with Cord Compression
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Choriocarcinoma is a malignant form of gestational trophoblastic neoplasia (GTN). It is characterized by the secretion of B-HCG. Although it can arise in any type of pregnancy, it is more common in patients with a history of molar pregnancy [1, 2].
Abnormal cytotrophoblast and syncytiotrophoblast with hyperplasia and anaplasia along with the absence of chorionic villi, hemorrhage, and necrosis are characteristic of choriocarcinoma. The most common distant sites of metastasis are the lungs, vagina, brain, and liver [1, 2, 3]. The mainstay of treatment of choriocarcinoma is multiagent chemotherapy. In majority of the cases, surgery and radiotherapy have got very limited role in the management. The spinal metastases are extremely rare in choriocarcinoma [4, 5, 6, 7, 8]. The standard of care in such cases does not exist due to paucity of the literature.
Here, we present an uncommon case of gestational choriocarcinoma with spinal metastases with spinal cord compression leading...
This study was supported by Rajiv Gandhi Cancer Institute and Research Centre, New Delhi.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Scott JR, Di Saia PJ, Hammond CB. Gestational trophoblastic neoplasms. In: Scott JR, Di Saia PJ, Hammond CB, editors. Danforth’s obstetrics and gynecology. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 1999. p. 927–37.Google Scholar
- 9.Sierra-Bergua B, Sánchez-Marteles M, Cabrerizo-García JL, Sanjoaquinconde I. Choriocarcinoma with pulmonary and cerebral metastases. Singap Med J. 2008;49:e286.Google Scholar