Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance
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Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme increasingly implicated in tumor progression and resistance to treatment. It is overexpressed in human cancers including glioblastoma, gastric, pancreatic, lung and colorectal cancers. The role of NNMT in cervical adenocarcinoma has not been studied thus far. We aimed to evaluate expression of NNMT in cervical adenocarcinoma and investigate its prognostic significance.
NNMT expression was assayed in 18 cases of cervical adenocarcinoma and 19 cases of benign cervical tissue. NNMT immunoreactivity was scored by multiplying staining intensity with percentage of immunoreactive cells.
The expression of NNMT was significantly higher in cervical adenocarcinoma than in benign tissue (p = 0.024). NNMT expression was significantly higher in patients with locally advanced than early cervical cancer (p = 0.031). NNMT expression was higher in patients with tumor size greater than 4 cm and in those with poorly differentiated tumors compared to patients with tumors of 4 cm or less and well-moderate differentiation, respectively (p = 0.044, p = 0.014).
Although on a preliminary level, this is the first study to detect an overexpression of NNMT in cervical adenocarcinoma and an increased expression associated with advanced stage, increased tumor size and poor differentiation. NNMT has been shown to carry prognostic and therapeutic importance in a variety of cancers, and it can be a potential treatment target in cervical adenocarcinomas.
KeywordsNicotinamide N-methyltransferase Cervical adenocarcinoma Stage Tumor size Tumor grade
S.A. contributed to idea development, data gathering and writing of manuscript. İ.H. contributed to data gathering and data analysis. S.U. contributed to data analysis and supervision. E.Ç. contributed to data analysis. Ç.Ç. contributed to supervision and the writing of manuscript.
This study was funded by the Scientific Research Project Endorsement (number 18401023).
Compliance with Ethical Standards
Conflict of interest
Authors declare no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors. This was a retrospective study of paraffin blocks and was approved by the Institutional Research Ethics Committee.
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