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Nicotinamide N-Methyltransferase Expression in Cervical Adenocarcinoma and Its Clinical Significance

  • Serra AkarEmail author
  • İsmail Harmankaya
  • Serdar Uğraş
  • Ersin Çintesun
  • Çetin Çelik
Original Article
  • 15 Downloads

Abstract

Introduction

Nicotinamide N-methyltransferase (NNMT) is a metabolic enzyme increasingly implicated in tumor progression and resistance to treatment. It is overexpressed in human cancers including glioblastoma, gastric, pancreatic, lung and colorectal cancers. The role of NNMT in cervical adenocarcinoma has not been studied thus far. We aimed to evaluate expression of NNMT in cervical adenocarcinoma and investigate its prognostic significance.

Methods

NNMT expression was assayed in 18 cases of cervical adenocarcinoma and 19 cases of benign cervical tissue. NNMT immunoreactivity was scored by multiplying staining intensity with percentage of immunoreactive cells.

Results

The expression of NNMT was significantly higher in cervical adenocarcinoma than in benign tissue (p = 0.024). NNMT expression was significantly higher in patients with locally advanced than early cervical cancer (p = 0.031). NNMT expression was higher in patients with tumor size greater than 4 cm and in those with poorly differentiated tumors compared to patients with tumors of 4 cm or less and well-moderate differentiation, respectively (p = 0.044, p = 0.014).

Conclusion

Although on a preliminary level, this is the first study to detect an overexpression of NNMT in cervical adenocarcinoma and an increased expression associated with advanced stage, increased tumor size and poor differentiation. NNMT has been shown to carry prognostic and therapeutic importance in a variety of cancers, and it can be a potential treatment target in cervical adenocarcinomas.

Keywords

Nicotinamide N-methyltransferase Cervical adenocarcinoma Stage Tumor size Tumor grade 

Notes

Author Contributions

S.A. contributed to idea development, data gathering and writing of manuscript. İ.H. contributed to data gathering and data analysis. S.U. contributed to data analysis and supervision. E.Ç. contributed to data analysis. Ç.Ç. contributed to supervision and the writing of manuscript.

Funding

This study was funded by the Scientific Research Project Endorsement (number 18401023).

Compliance with Ethical Standards

Conflict of interest

Authors declare no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by any of the authors. This was a retrospective study of paraffin blocks and was approved by the Institutional Research Ethics Committee.

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Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Division of Gynecologic Oncology, Department of Obstetrics and GynecologySelcuk University Medical SchoolKonyaTurkey
  2. 2.Department of PathologySelcuk University Medical SchoolKonyaTurkey
  3. 3.Department of Obstetrics and GynecologySelcuk University Medical SchoolKonyaTurkey

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