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Acute Myeloid Leukemia After Treatment of Early Breast Cancer: Case Report and Literature Review

  • Issam LalyaEmail author
  • Ismail Essadi
  • Rhizlane Belbaraka
  • Abdelhamid El Omrani
  • Mouna Khouchani
Case Report

Abstract

Background

Therapy-related acute myeloid leukemia has been widely accepted for decades as one of the most serious long-term complications of treatment for early breast cancer.

Case

We report the case of a patient with therapy-related acute myeloid leukemia that may have been caused by regional radiation, chemotherapy, or endocrine therapy after surgery. A 35-year-old female was diagnosed 7 years ago as having stage IIA left breast cancer; she was treated by conservative surgery, followed by chemotherapy, radiotherapy, and endocrine therapy for 5 years. After 1 year of active follow-up, she presented with complaints of mild fever, weakness, loss of appetite, weight loss, and multiple bruises all over the body. Complete blood count revealed a hemoglobin level of 4 g/dl and total leukocyte count of 40,000 cells/mm3, with multiple blast cells in peripheral smear. Bone marrow biopsy and immunophenotyping established the diagnosis as AML. Before starting the treatment, she died following multiple organ failure.

Keywords

Therapy-related acute myeloid leukemia Chemotherapy Radiotherapy Endocrine therapy Breast cancer 

Notes

Acknowledgements

Special thanks are due to the Faculty of Medicine and Pharmacy of Marrakech and Cadi Ayyad University of Marrakech.

Authors’ contributions

IL and IE performed the research and wrote the manuscript. RB, AE, and MK coordinated the research and revised and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

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Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Radiation-Oncology DepartmentMohammed VI University HospitalMarrakechMorocco
  2. 2.Faculty of Medicine and PharmacyCadi Ayyad UniversityMarrakechMorocco
  3. 3.Medical Oncology DepartmentAvicenne Military HospitalMarrakechMorocco
  4. 4.Medical Oncology DepartmentMohammed VI University HospitalMarrakechMorocco

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