Acute Myeloid Leukemia After Treatment of Early Breast Cancer: Case Report and Literature Review
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Therapy-related acute myeloid leukemia has been widely accepted for decades as one of the most serious long-term complications of treatment for early breast cancer.
We report the case of a patient with therapy-related acute myeloid leukemia that may have been caused by regional radiation, chemotherapy, or endocrine therapy after surgery. A 35-year-old female was diagnosed 7 years ago as having stage IIA left breast cancer; she was treated by conservative surgery, followed by chemotherapy, radiotherapy, and endocrine therapy for 5 years. After 1 year of active follow-up, she presented with complaints of mild fever, weakness, loss of appetite, weight loss, and multiple bruises all over the body. Complete blood count revealed a hemoglobin level of 4 g/dl and total leukocyte count of 40,000 cells/mm3, with multiple blast cells in peripheral smear. Bone marrow biopsy and immunophenotyping established the diagnosis as AML. Before starting the treatment, she died following multiple organ failure.
KeywordsTherapy-related acute myeloid leukemia Chemotherapy Radiotherapy Endocrine therapy Breast cancer
Special thanks are due to the Faculty of Medicine and Pharmacy of Marrakech and Cadi Ayyad University of Marrakech.
IL and IE performed the research and wrote the manuscript. RB, AE, and MK coordinated the research and revised and approved the final manuscript.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest.
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