Aggressive Angiomyxoma: A Rare Cause of Recurrent Vulval Swelling

  • Renu Arora
  • Preeti Bala SinghEmail author
  • Neelam Sahani
Case Report


This is a case report of a 28-year female with aggressive angiomyxoma who presented with recurrent vulval swelling for which she was operated four times. First time, at the age of 19 years thinking it to be a Bartholin’s duct cyst, that on histopathology found to be angiomyxoma. Swelling recurred as left labial mass within a year of surgery. Second time, she underwent wide excision of the left labial mass, and on immunohistochemistry, it was positive for estrogen and progesterone receptors for which she was offered hormonal treatment, but she denied. Third time, she underwent robotic surgery because upper extent of tumor was deep in the pelvis and was not approachable by perineal route. After 2 years, swelling recurred again for which she got operated fourth time after her pregnancy. Now she has been given GnRH agonist and is being followed up for recurrence.


Angiomyxoma Mesenchymal tumor Vulval swelling Recurrent tumor Bartholin’s duct cyst 


Compliance with Ethical Standards

Conflict of interest

The authors declare no conflict of interest whatsoever arising out of the publication of this manuscript.

Informed Consent

Patient has given her informed consent for the case report to be published.

Ethical Approval

This study does not contain any studies with human participants or animals performed by any of the authors.


  1. 1.
    Steeper TA, Rosai J. Aggressive angiomyxoma of the female pelvis and perineum. Report of nine cases of a distinctive type of gynaecologic soft tissue neoplasm. Am J Surg Pathol. 1983;7(5):463–75.CrossRefGoogle Scholar
  2. 2.
    Chan YM, Hon E, Ngai SW, Ng TY, Wong LC. Aggressive angiomyxoma in females: is radical resection the only option? Acta Obstet Gynecol Scand. 2000;79(3):216–20.CrossRefGoogle Scholar
  3. 3.
    Gungor T, Zengeroglu S, Kaleli A, Kuzey GM. Aggressive angiomyxoma of the vulva and vagina. A common problem: misdiagnosis. Eur J Obstet Gynecol Reprod Biol. 2004;112:114–6.CrossRefGoogle Scholar
  4. 4.
    Fetsch JF, Laskin WB, Lefkowitz M, Kindblom L, Meis- Kindblom JM. Aggressive angiomyxoma. A clinicopathologic study of 29 female patients. Cancer. 1996;78:79–90.CrossRefGoogle Scholar
  5. 5.
    Behranwala KA, Thomas JM. ‘Aggressive’ angiomyxoma: a distinct clinical entity. Eur J Surg Oncol. 2003;29:559–63.CrossRefGoogle Scholar
  6. 6.
    Granter SR, Nucci MR, Fletcher CD. Aggressive angiomyxoma: reappraisal of its relationship to angiomyofibroblastoma in a series of 16 cases. Histopathology. 1997;30(1):3–10.CrossRefGoogle Scholar
  7. 7.
    Fine BA, Munoz AK, Litz CE, Gershenson DM. Primary medical management of recurrent aggressive angiomyxoma of the vulva with a gonadotropin-releasing hormone agonist. Gynecol Oncol. 2001;81(1):120–2.CrossRefGoogle Scholar
  8. 8.
    McCluggage WG, Jamieson T, Dobbs SP, Grey A. Aggressive angiomyxoma of the vulva: dramatic response to gonadotropin-releasing hormone agonist therapy. Gynecol Oncol. 2006;100(3):623–5.CrossRefGoogle Scholar

Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyVMMC & Safdarjung HospitalNew DelhiIndia
  2. 2.Department of Obstetrics and GynecologyAIIMS GorakhpurGorakhpurIndia
  3. 3.Department of PathologyVMMC & SJHNew DelhiIndia

Personalised recommendations