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Elevated Ovarian Germ Cell Tumour Markers in a Case of Disseminated Tuberculosis

  • Dipanwita BanerjeeEmail author
  • Rashmi Chakraborty
  • Amit Mandal
  • Manisha Vernekar
  • Chandrima Ray
  • Ranajit Mandal
Case Report
  • 6 Downloads

Abstract

India has the highest burden of both pulmonary and extrapulmonary tuberculosis (TB). Chronic untreated case of tuberculosis may spread to other abdominal structures causing disseminated TB often mimicking signs and symptoms of abdominal malignancy. We present a case of ovarian tumour with high ovarian germ cell tumour marker levels, but the final diagnosis was disseminated tuberculosis. Patient responded well to antitubercular therapy, and serum CA125, LDH, AFP and beta-HCG became normal. In our case, elevation of tumour markers was considered as a reflection of disseminated TB, so tumour markers were normal at the end of antitubercular treatment.

Keywords

Tuberculosis mimics ovarian cancer Raised germ cell markers in disseminated tuberculosis Unusual presentation of disseminated TB HCG and TB AFP and TB 

Abbreviations

WHO

World Health Organization

TB

Tuberculosis

AIDS

Acquired immunodeficiency syndrome

CA 125

Cancer antigen 125

AFP

Alpha-fetoprotein

BHCG

Beta-human chorionic gonadotropin

LDH

Lactate dehydrogenase

CAT

Computerised abdominal tomography

HIV

Human immunodeficiency virus

HbsAg

Hepatitis B surface antigen

AFB

Acid-fast bacilli

ZN stain

Ziehl–Neelsen stain

ATT

Antitubercular treatment

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving Human Participants and/or Animals

The patient received standard of care treatment.

Informed Consent

Informed consent from the patient was obtained before preparing the manuscript.

References

  1. 1.
    Global Tuberculosis Report, World Health organisation, 20th Edition. 2015. http://www.who.int/tb/publications/global_report/gtbr15_main_text.pdf. Accessed 30 Aug 2018.
  2. 2.
    Abi-Fadel F, Gupta K. Acute respiratory distress syndrome with miliary tuberculosis: a fatal combination. J Thorac Dis. 2013;5(1):E1–4.  https://doi.org/10.3978/j.issn.2072-1439.2012.07.02.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Sahin F, Yildiz P. Serum CA-125: biomarker of pulmonary tuberculosis activity and evaluation of response to treatment. Clin Invest Med. 2012;35:223–8.CrossRefGoogle Scholar
  4. 4.
    Sharma PR, Jain S, Bamezai RNK, Tiwari PK. Utility of serum LDH isoforms in the assessment of mycobacterium tuberculosis induced pathology in TB patients of Sahariya tribe. Indian J Clin Biochem. 2010;25(1):57–63.  https://doi.org/10.1007/s12291-010-0012-3.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Rakha S, Bayliss C, Sanderson F, Smith R, Seckl M, Savage P. Pituitary hCG production and cerebral tuberculosis mimicking disease progression during chemotherapy for an advanced ovarian germ cell tumour. BMC Cancer. 2010;10:338.  https://doi.org/10.1186/1471-2407-10-338.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Department of Gynaecological OncologyChittaranjan National Cancer InstituteKolkataIndia

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