Detection of Regional Lymph Node Metastasis by 18-FDG PET/CT in Patients with Endometrial Cancer
- 25 Downloads
To evaluate the accuracy of 18F-FDG PET/CT in detecting regional lymph node metastasis in patients with endometrial cancer.
A retrospective analysis was done for 50 patients having biopsy-proven endometrial cancer who underwent FDG PET/CT as a part of preoperative evaluation. All of these underwent Type I hysterectomy with lymphadenectomy either by open or robot-assisted surgery. PET/CT findings were then compared with the final histopathology. The criterion for malignancy on PET/CT images was increased FDG uptake by a lymph node independent of its size.
Hyper-metabolic FDG-avid lymph nodes were present in 9 out of 50 patients. Twelve patients had metastasis to lymph nodes on histopathology, and 38 were negative for nodal metastasis. The overall sensitivity, specificity, positive and negative predictive value and accuracy of PET/CT for detecting nodal metastases were 66.67, 97.4, 88.9, 90.24 and 90%, respectively.
Though FDG PET/CT has a high specificity and negative predictive value, its accuracy in diagnosing nodal metastasis in patients with endometrial cancer is limited because of its low sensitivity.
KeywordsEndometrial cancer PET/CT Nodal metastasis Imaging
Compliance with Ethical Standards
Conflict of interest
All the authors declare no conflict of interest.