Molar Pregnancy with Hyperthyroidism: A Therapeutic Challenge

  • Akanksha SharmaEmail author
  • Krishna Agarwal
  • Gauri Gandhi
Case report


Gestational trophoblastic disease is a rare complication of pregnancy that may be associated with an increased likelihood of hyperthyroidism secondary to rising levels of human chorionic gonadotrophin (HCG). Most of these cases remain undiagnosed leading to thyrotoxic crisis during and after operative intervention. We report a case of molar pregnancy with secondary hyperthyroidism who presented to us with a history of vaginal bleeding, palpitations, hyperemesis and abdominal distension. She had hysterotomy under general anaesthesia but went in acute cardio-pulmonary distress during the post-operative period for which she required prolonged intubation and tracheostomy. She became euthyroid after 2 weeks with anti-thyroid drugs. In view of ultrasound findings and rising beta HCG, a diagnosis of invasive mole was made and was started on chemotherapy. She responded well to the treatment and was finally discharged after normalisation of HCG values.


Complete hydatidiform mole Molar pregnancy Gestational trophoblastic disease Chemotherapy Hyperthyroidism 


Compliance with Ethical Standards

Conflict of interest

Akanksha Sharma, Krishna Agarwal and Gauri Gandhi declare that they have no conflict of interest.

Informed Consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from all patients for being included in the study.


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Copyright information

© Association of Gynecologic Oncologists of India 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyMaulana Azad Medical College and Lok Nayak HospitalNew DelhiIndia

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