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Screening by CA125 and Transvaginal Ultrasound for Ovarian Cancer in Postmenopausal Women: A Pilot Study in Malwa Region of Punjab

  • Ratika Samtani
  • Roumi Deb
Original Article
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Abstract

Purpose

The causes of ovarian cancer are multifold and the incidence is increasing gradually. The aim of the study is to screen for ovarian cancer at the population level among postmenopausal women belonging to a rural belt, Malwa region of Punjab, India, where cancer incidence is on a rise.

Methods

A total of 726 postmenopausal women from 33 villages of Talwandi Sabo block, Bathinda district, Punjab, India, participated in the ovarian cancer screening. Serum CA125 estimation followed by transvaginal ultrasound was done in order to detect any signs of ovarian carcinoma.

Results

Mean level of CA125 was 8.15 (SD 11.59) U/ml with an interquartile range of 3.0–8.81 U/ml. Of the 726 postmenopausal women screened for ovarian cancer risk, 24 women (3.3%) were observed with elevated levels of CA125 (> 35 U/ml). No case of complex cyst/ovarian carcinoma was detected. Mean level of CA125 was higher with increasing age at menopause. 93.4% of the women were agriculturalists. A higher mean CA125 level was observed in women involved in agriculture (8.05 U/ml) as compared to non-agricultural women (5.87 U/ml).

Conclusions

The proportion of women detected with abnormal CA125 levels in the present study is quite large, and women of the region should be monitored regularly for any increase in CA125 levels. It is the earnest need of the hour to organize large-scale awareness and screening camps in villages of Talwandi Sabo block, Punjab, India, especially those in remote locations having minimum access to medical care facilities.

Keywords

CA125 Ovarian cancer Postmenopausal women Menopause Agriculture 

Abbreviations

OC

Ovarian cancer

AAR

Age-adjusted incidence rate

EDC

Endocrine-disrupting chemicals

CA125

Cancer antigen 125

ELISA

Enzyme-linked immunosorbent assay

TVUS

Transvaginal ultrasound

PLCO

Prostate, lung, colorectal and ovarian screening trial

Notes

Acknowledgements

This study was supported by funding from Rajiv Gandhi Centre for Biotechnology, Department of Biotechnology (DBT), Ministry of Science and Technology, India (6242-P86/RGCB/PMD/DBT/RKSN/2015), awarded to Dr Ratika Samtani. The authors express deep gratitude to the village heads and women of Punjab, India, who participated in the study and contributed to the research work.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Association of Gynecologic Oncologists of India 2018

Authors and Affiliations

  1. 1.Amity Institute of Anthropology, Room 219, J3 BlockAmity University NoidaNoidaIndia

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