Role of the Appropriateness of the Pelvic Lymphadenectomy and Adjuvant Radiation Therapy in Early-Stage Poorly Differentiated Endometrial Carcinoma

  • Valerio NardoneEmail author
  • Paolo Tini
  • Luisa Marciello
  • Giuseppe Battaglia
  • Pierpaolo Pastina
  • Monica Crociani
  • Chiara Cancemi
  • Marta Vannini
  • Lucio Sebaste
  • Luigi Pirtoli
Original Article



With this work, we intend to investigate the prognostic role of the pelvic lymphadenectomy, analyzing the pattern of recurrence in poorly differentiated endometrial carcinoma.

Methods and Materials

Our study analyzes a total of 98 patients affected by early-stage (T1/T2) poorly differentiated endometrial carcinoma. Detailed data concerning clinical presentation, pathology, adjuvant treatment, and outcomes were collected and correlated with disease-free survival (DFS), further distinguished in local and distant DFS, and overall survival (OS). The extent of the lymphadenectomy was considered appropriated when a number of 12 lymph nodes were removed.


The only characteristic significantly associated with locoregional DFS was the use of adjuvant radiation therapy (p: 0.003), whereas the use of adjuvant radiation therapy (RT, p: 0.004), the appropriateness of lymphadenectomy (p: 0.019), and the higher age (> 65 years, p: 0.037) are associated with distance DFS. The only significant variable associated with OS was the higher age (p: 0.025). On multivariate analysis, RT was correlated (p: 0.017) with locoregional DFS, whereas RT (p: 0.019) and age (p: 0.048) were correlated with distance DFS. The multivariate analysis of OS showed that the only parameter associated was the age (p: 0.047).


The results of our study underline the importance of an appropriate lymphadenectomy and the selection of the correct adjuvant strategy in the treatment of early-stage poorly differentiated endometrial carcinoma.


Poorly differentiated endometrial carcinoma Lymphadenectomy Radiation therapy Chemotherapy Gynecology oncology 



Endometrial cancer


Extension of primary tumor


Lymph nodal status


Radiation therapy




Disease-free survival


Overall survival


Compliance with Ethical Standards

Conflict of interest

All the authors declare no conflicts of interest.


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Copyright information

© Association of Gynecologic Oncologists of India 2018

Authors and Affiliations

  • Valerio Nardone
    • 1
    Email author
  • Paolo Tini
    • 1
  • Luisa Marciello
    • 2
  • Giuseppe Battaglia
    • 1
  • Pierpaolo Pastina
    • 1
  • Monica Crociani
    • 1
  • Chiara Cancemi
    • 1
  • Marta Vannini
    • 1
  • Lucio Sebaste
    • 1
  • Luigi Pirtoli
    • 1
  1. 1.Unit of Radiation OncologyUniversity Hospital of SienaSienaItaly
  2. 2.Unit of Radiation OncologyHospital of PratoPratoItaly

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