A Recurrent Granulosa Cell Tumor of the Ovary After 20 Years

  • Renu Ranga
  • Pariseema DaveEmail author
  • Anusha Kamath
  • Garima Pandey
Case report



Adult-type granulosa cell tumors of the ovary are rare tumors. These tumors characteristically have high recurrence rates (10–15%), sometimes many years after the original diagnosis, and so lifelong follow is warranted for these patients.

Case Report

A 52-year-old female presented with a history of hysterectomy with ovarian mass removal 20 yrs back. She presented with huge abdominopelvic mass. Imaging showed abdominopelvic mass (18 × 10 × 24 cm), adherent to large bowel with multiple liver metastases (subcapsular and parenchymal largest 46 × 47 mm). Inhibin B (240 pg/ml) was raised. Exploratory laparotomy followed by ovarian mass removal, bowel resection anastomosis with proximal ileostomy and removal of hepatic metastasis was done. It was a suboptimal surgery, and residual disease was a 2-cm nodule near porta hepatis. Post-surgery inhibin was 70 pg/ml. Postoperatively, she received 6 doses of adjuvant chemotherapy (carboplatin and paclitaxel) and on regular follow-up.


Due to high chance of recurrence even years after apparent clinical cure of the primary tumor, lifelong follow-up with clinical examination and tumor markers like inhibin B is required.


Granulosa cell tumor Metastatic liver tumor Recurrence Inhibin B Adjuvant chemotherapy 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they do not have any conflicts of interest.


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Copyright information

© Association of Gynecologic Oncologists of India 2018

Authors and Affiliations

  • Renu Ranga
    • 1
  • Pariseema Dave
    • 1
    Email author
  • Anusha Kamath
    • 1
  • Garima Pandey
    • 1
  1. 1.Department of Gynecologic OncologyGujarat Cancer and Research InstituteAhmedabadIndia

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