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The Background and Scope of Polyphosphazenes as Biomedical Materials

  • Harry R. AllcockEmail author
Article
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Part of the following topical collections:
  1. Special Edition: Quartet editor Alexander Andrianov

Abstract

Although many traditional organic polymers have been evaluated for uses in biology and medicine, relatively few have proved to be satisfactory for crucial uses such as surgical sutures or mesh, tissue engineering substrates, controlled drug delivery, or soft matter. A reason for this is that most large-volume commercial polymers are optimized for some mechanical engineering purpose, and biomedical compatibility or bioerodibility is not one of the target properties. Thus, biomedical scientists and engineers have been forced to improvise and compromise by using widely available non-biological polymers, mainly because those materials are already available in commercial quantities. Polyphosphazenes offer an opportunity to solve many of these problems.

Lay Summary

A crucial need exists for new polymers that can be utilized in orthopedics, cardiovascular, dental, neural, or drug delivery applications, yet very few long-existing polymers have properties that are ideal for these medical uses. Our research seeks to design and find methods to synthesize polymeric materials that are specifically designed to solve a range of medical challenges. In our program, we make use of an unusual polymer backbone comprised of alternating phosphorus and nitrogen atoms to which are attached a wide range of organic side groups. This system is unique in the wide range of different property combinations that can be generated, and many of these combinations can be matched precisely to the needs of medical materials.

Keywords

Polymers Polyphosphazenes Synthesis Biomedical Elastomers Bioerodible Biostable 

Notes

Acknowledgments

The author acknowledges the contributions to our program by 108 graduate students, numerous undergraduates, 36 postdoctoral scientists, and many collaborators. The biomedical funding at different times has been through the U.S. National Institutes of Health, National Science Foundation, the U.S. Army Research Office, The Pennsylvania State University, and private donations.

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Copyright information

© The Regenerative Engineering Society 2019

Authors and Affiliations

  1. 1.Departments of Chemistry, Chemical Engineering, and BioengineeringThe Pennsylvania State UniversityUniversity ParkUSA

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