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Journal of Medical and Biological Engineering

, Volume 39, Issue 4, pp 583–595 | Cite as

Study on the Effect and the Eliminate Method of Preloading Force on the Compression Tests of Liver Tissue

  • Lingtao Yu
  • Jing YangEmail author
  • Lan Wang
  • Wenjie Wang
  • Yusheng Yan
Original Article
  • 53 Downloads

Abstract

The mechanical response of liver tissue is commonly characterized by compression tests of specimens. The preloading force between the compression platform and the specimen is often ignored in compression tests. In the present study, unconfined and no-slip compression tests of liver tissue with preloading forces were performed. Based on collected mechanical responses of unconfined compression tests with five preloading forces, the influences of the preloading force on the constitutive model parameters and elastic moduli were analyzed. An indirect optimization method was proposed to eliminate the influence of the preloading force. Pre-strain caused by the preloading force is considered in the constitutive model in this method. The collected mechanical responses are applied to obtain the constitutive model and preloading model PUCT parameters with proposed indirect optimization method. Based on the optimization constitutive model parameters, FE models with different sample sizes were established. Preloading model PNSCT was established by numerical tests with different sample sizes. Based on the preloading model PNSCT, the collected mechanical response of no-slip compression test with a preloading force (0.05 N) was corrected. The results show that the indirect optimization method can eliminate the effect of the preloading force on liver tissue properties, and the corrected mechanical response is closer to the actual mechanical response.

Keywords

Liver tissue Compression test Preloading force Constitutive model Optimization method 

Notes

Acknowledgement

This paper is funded by the Natural Science Foundation of Heilongjiang Province (F2015034). The Fundamental Research Funds for the Central Universities (HEUCFM170703).

Compliance with Ethical Standards

Conflict of interest

The authors have no conflicts of interest to declare.

References

  1. 1.
    Fung, Y. C. (1993). Biomechanics: Mechanical properties of living tissues (2nd ed.). New York: Springer.CrossRefGoogle Scholar
  2. 2.
    Lister, K., Gao, Z., & Desai, J. P. (2011). Development of in vivo constitutive models for liver: application to surgical simulation. Annals of Biomedical Engineering, 39, 1060–1073.CrossRefGoogle Scholar
  3. 3.
    Giorgio, Mattei, & Arti, Ahluwalia. (2016). Sample, testing and analysis variables affecting liver mechanical properties: A review. Acta Biomaterialia, 45, 60–71.CrossRefGoogle Scholar
  4. 4.
    Karol, Miller. (2005). Method of testing very soft biological tissues in compression. Journal of Biomechanics, 38, 153–158.CrossRefGoogle Scholar
  5. 5.
    Karol, Miller. (2001). How to test very soft biological tissues in extension. Journal of Biomechanics, 34, 651–657.CrossRefGoogle Scholar
  6. 6.
    Umale, S., Decka, C., Bourdet, N., et al. (2013). Experimental mechanical characterization of abdominal organs: liver, kidney & spleen. Journal of the Mechanical Behavior of Biomedical Materials, 17, 22–33.CrossRefGoogle Scholar
  7. 7.
    Schwartz, J. M., Denninger, M., Rancourt, D., et al. (2005). Modelling liver tissue properties using a non-linear visco-elastic model for surgery simulation. Medical Image Analysis, 9, 103–112.CrossRefGoogle Scholar
  8. 8.
    Chui, C., Kobayashi, E., Chen, X., Hisada, T., & Sakuma, I. (2007). Transversely isotropic properties of porcine liver tissue: experiments and constitutive modelling. Medical Biological Engineering Computing, 45, 99–106.CrossRefGoogle Scholar
  9. 9.
    Karimi, A., & Shojaei, A. (2018). An experimental study to measure the mechanical properties of the human liver. Digestive Diseases, 36, 150–155.CrossRefGoogle Scholar
  10. 10.
    Fulin, Lei, & Szeri, A. Z. (2007). Inverse analysis of constitutive models: biological soft tissues. Journal of Biomechanics, 40, 936–940.CrossRefGoogle Scholar
  11. 11.
    Fu, Y. B., & Chui, C. K. (2014). Modelling and simulation of porcine liver tissue indentation using finite element method and uniaxial stress–strain data. Journal of Biomechanics, 47, 2430–2435.CrossRefGoogle Scholar
  12. 12.
    Kobayashi, Y., Kato, A., Watanabe, H., et al. (2012). Modeling of viscoelastic and nonlinear material properties of liver tissue using fractional calculations. Journal of Biomechanical Science and Engineering, 7, 177–187.CrossRefGoogle Scholar
  13. 13.
    Raghunathan, S., Evans, D., & Sparks, J. L. (2010). Poroviscoelastic modeling of liver biomechanical response in unconfined compression. Annals of Biomedical Engineering, 38, 1789–1800.CrossRefGoogle Scholar
  14. 14.
    Esra, Roan, & Kumar, Vemaganti. (2007). The nonlinear material properties of liver tissue determined from no-slip uniaxial compression experiments. Journal of Biomechanical Engineering, 129, 450–456.Google Scholar
  15. 15.
    Zhan, Gao, Lister, Kevin, & Desai, Jaydev P. (2010). Constitutive modeling of liver tissue: Experiment and theory. Annals of Biomedical Engineering, 38, 505–516.CrossRefGoogle Scholar
  16. 16.
    Yeh, W.-C., Li, P.-C., Jeng, Y.-M., et al. (2002). Elastic modulus measurements of human liver and correlation with pathology. Ultrasound in Medicine Biology, 28, 467–474.CrossRefGoogle Scholar
  17. 17.
    Clarke, E. C., Cheng, S., Green, M., et al. (2011). Using static preload with magnetic resonance elastography to estimate large strain viscoelastic properties of bovine liver. Journal of Biomechanics, 44, 2461–2465.CrossRefGoogle Scholar
  18. 18.
    Mehmet, Ayyildiz, Soner, Cinoglu, & Basdogan, Cagatay. (2015). Effect of normal compression on the shear modulus of soft tissue in rheological measurements. Journal of the Mechanical Behavior of Biomedical Materials, 49, 235–243.CrossRefGoogle Scholar
  19. 19.
    Mattei, G., Tirella, A., Gallone, G., & Ahluwalia, A. (2014). Viscoelastic characterisation of pig liver in unconfined compression. Journal of Biomechanics, 47, 2641–2646.CrossRefGoogle Scholar
  20. 20.
    Acosta, Santamaría V. A., García, Aznar J. M., Ochoa, I., et al. (2013). Effect of sample pre-contact on the experimental evaluation of cartilage mechanical properties. Experimental Mechanics, 53, 911–917.CrossRefGoogle Scholar
  21. 21.
    Zhang, X., Fisher, M. B., Woo, S. L.-Y., et al. (2007). The assumption of a negligible preload on the determination of viscoelastic properties based on the quasi-linear viscoelastic (QLV) theory. In: IEEE/ICME international conference on complex medical engineering. IEEE, 2007, 1617–1620.Google Scholar
  22. 22.
    Miller, K. (2000). Constitutive modelling of abdominal organs. Journal of Biomechanics, 33, 367–373.CrossRefGoogle Scholar
  23. 23.
    Chagnon, G., Rebouah, M., & Favier, D. (2015). Hyperelastic energy densities for soft biological tissues: A review. Journal of Elasticity, 120, 129–160.MathSciNetCrossRefzbMATHGoogle Scholar
  24. 24.
    Zhang, W., Wen, J. B., Zhu, Y. C., et al. (2017). Multi-objective scheduling simulation of flexible job-shop based on multi-population genetic algorithm. International Journal of Simulation Modelling, 16, 313–321.CrossRefGoogle Scholar
  25. 25.
    Huang, C. Y., Wang, V. M., Flatow, E. L., et al. (2009). Temperature-dependent viscoelastic properties of the human supraspinatus tendon. Journal of Biomechanics, 42, 546–549.CrossRefGoogle Scholar
  26. 26.
    Mattei, G., Di Patria, V., Tirella, A., et al. (2014). Mechanostructure and composition of highly reproducible decellularized liver matrices. Acta Biomaterialia, 10, 875–882.CrossRefGoogle Scholar
  27. 27.
    Yarpuzlu, B., Ayyildiz, M., Tok, O. E., et al. (2014). Correlation between the mechanical and histological properties of liver tissue. Journal of the Mechanical Behavior of Biomedical Materials, 29, 403–416.CrossRefGoogle Scholar

Copyright information

© Taiwanese Society of Biomedical Engineering 2018

Authors and Affiliations

  • Lingtao Yu
    • 1
  • Jing Yang
    • 1
    Email author
  • Lan Wang
    • 1
  • Wenjie Wang
    • 1
  • Yusheng Yan
    • 1
  1. 1.College of Mechanical and Electrical EngineeringHarbin Engineering UniversityHarbinChina

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