Journal of Medical and Biological Engineering

, Volume 39, Issue 4, pp 583–595 | Cite as

Study on the Effect and the Eliminate Method of Preloading Force on the Compression Tests of Liver Tissue

  • Lingtao Yu
  • Jing YangEmail author
  • Lan Wang
  • Wenjie Wang
  • Yusheng Yan
Original Article


The mechanical response of liver tissue is commonly characterized by compression tests of specimens. The preloading force between the compression platform and the specimen is often ignored in compression tests. In the present study, unconfined and no-slip compression tests of liver tissue with preloading forces were performed. Based on collected mechanical responses of unconfined compression tests with five preloading forces, the influences of the preloading force on the constitutive model parameters and elastic moduli were analyzed. An indirect optimization method was proposed to eliminate the influence of the preloading force. Pre-strain caused by the preloading force is considered in the constitutive model in this method. The collected mechanical responses are applied to obtain the constitutive model and preloading model PUCT parameters with proposed indirect optimization method. Based on the optimization constitutive model parameters, FE models with different sample sizes were established. Preloading model PNSCT was established by numerical tests with different sample sizes. Based on the preloading model PNSCT, the collected mechanical response of no-slip compression test with a preloading force (0.05 N) was corrected. The results show that the indirect optimization method can eliminate the effect of the preloading force on liver tissue properties, and the corrected mechanical response is closer to the actual mechanical response.


Liver tissue Compression test Preloading force Constitutive model Optimization method 



This paper is funded by the Natural Science Foundation of Heilongjiang Province (F2015034). The Fundamental Research Funds for the Central Universities (HEUCFM170703).

Compliance with Ethical Standards

Conflict of interest

The authors have no conflicts of interest to declare.


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Copyright information

© Taiwanese Society of Biomedical Engineering 2018

Authors and Affiliations

  • Lingtao Yu
    • 1
  • Jing Yang
    • 1
    Email author
  • Lan Wang
    • 1
  • Wenjie Wang
    • 1
  • Yusheng Yan
    • 1
  1. 1.College of Mechanical and Electrical EngineeringHarbin Engineering UniversityHarbinChina

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