Advertisement

Science China Materials

, Volume 61, Issue 12, pp 1627–1628 | Cite as

Site-specific protein-polymer conjugate micelles with dramatically enhanced pharmacology

Highlights
  • 34 Downloads

References

  1. 1.
    Walsh G. Biopharmaceutical benchmarks 2014. Nat Biotechnol, 2014, 32: 992–1000CrossRefGoogle Scholar
  2. 2.
    Leader B, Baca QJ, Golan DE. Protein therapeutics: a summary and pharmacological classification. Nat Rev Drug Discov, 2008, 7: 21–39CrossRefGoogle Scholar
  3. 3.
    Dusheiko G. Side effects of a interferon in chronic hepatitis C. Hepatology, 1997, 26: 112S–121SCrossRefGoogle Scholar
  4. 4.
    Harris JM, Chess RB. Effect of PEGylation on pharmaceuticals. Nat Rev Drug Discov, 2003, 2: 214–221CrossRefGoogle Scholar
  5. 5.
    Liu X, Sun J, Gao W. Site-selective protein modification with polymers for advanced biomedical applications. Biomaterials, 2018, 178: 413–434CrossRefGoogle Scholar
  6. 6.
    Rajender Reddy K, Modi MW, Pedder S. Use of peginterferon alfa-2a (40 KD) (Pegasys®) for the treatment of hepatitis C. Adv Drug Deliver Rev, 2002, 54: 571–586CrossRefGoogle Scholar
  7. 7.
    Talpaz M, Rakhit A, Rittweger K, et al. Phase I evaluation of a 40-kDa branched-chain long-acting pegylated IFN-2a with and without cytarabine in patients with chronic myelogenous leukemia. Clin Cancer Res, 2005, 11: 6247–6255CrossRefGoogle Scholar
  8. 8.
    Foser S, Schacher A, Weyer KA, et al. Isolation, structural characterization, and antiviral activity of positional isomers of monopegylated interferon a-2a (PEGASYS). Protein Expres Purif, 2003, 30: 78–87CrossRefGoogle Scholar
  9. 9.
    Wang G, Hu J, Gao W. Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy. Sci China Mater, 2017, 60: 563–570CrossRefGoogle Scholar
  10. 10.
    Liu X, Sun M, Sun J, et al. Polymerization induced self-assembly of a site-specific interferon a-block copolymer conjugate into micelles with remarkably enhanced pharmacology. J Am Chem Soc, 2018, 140: 10435–10438CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular EngineeringPeking UniversityBeijingChina

Personalised recommendations