Low-Dose Radiation Prevents Chemotherapy-Induced Cardiotoxicity
Purpose of Review
In this review, we will address the cardioprotective effect of low-dose radiation (LDR) on chemotherapeutic agents.
Cancer has become the most important cause of death in the world, and the morbidity and mortality are gradually increased. The application of anti-tumor drugs is an important therapeutic tool for cancer therapy at present, while its potential cardiotoxicity cannot be ignored. How to prevent and reduce the occurrence of cardiotoxicities needs further exploration.
LDR induces an adaptive or hormetic response in cells and tissues, showing a tolerance to subsequently high dose of radiation- or chemical-induced damage in vitro and in vivo. LDR may exert its cardioprotective effects through different mechanisms, such as stimulating the proliferation of normal cells during anti-tumor therapy, enhancing anti-tumor immunity, stimulating antioxidative functions in normal tissues, activating DNA damage repair system, and improving metabolic function in normal tissues. Therefore, there may be a potential to apply LDR as an adjunct to myocardial protection for anti-tumor therapy.
KeywordsLow-dose radiation Adaptive response Hormesis Cardiotoxicity Cancer drug
Works from the authors were supported in part by grants from the Industrial Technology Research and Development (2016C055-2), the International Science and Technology Cooperation Project (20160414004GH), and the National Natural Science Foundation of China (81272471).
Compliance with Ethical Standards
Conflict of Interest
Jing Xu, Dandan Liu, Shengxiang Xiao, Xinxin Meng, Di Zhao, Xin Jiang, Xue Jiang, Lu Cai and Hongyu Jiang declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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