The Ethics of Chimera Creation in Stem Cell Research
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Purpose of review
To summarize and clarify the main ethical issues surrounding the generation and use of human-animal chimeras in stem cell research.
US federal funding remains restricted for certain forms of human-animal chimera research despite the widespread promulgation and acceptance of national and international stem cell-specific research guidelines.
Stem cell-based human-animal chimera research can promote advances in basic human developmental biology, disease modeling, and new drug discoveries. National and international guidelines for this form of stem cell research have been developed over the past several years but ethical concerns persist around human dignity and the possible moral humanization of chimeric animals. These concerns can be defused and ought to be replaced with a more tractable focus on animal welfare.
KeywordsChimeras Stem cells Ethics Research oversight Animal welfare
Compliance with Ethical Standards
Conflict of Interest
Dr. Insoo Hyun reports no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance
- 3.• Wu J, et al. Interspecies chimerism with mammalian pluripotent stem cells. Cell. 2017;168:473–86. This study shows that an intermediate human pluripotent stem cell type can generate limited contribution to post-implantation pig embryos. It is a significant first step toward the goal of eventually producing transplantable human organs in livestock animals.CrossRefPubMedPubMedCentralGoogle Scholar
- 4.• Rashid T, Kobayashi T, Nakauchi H. Revisiting the flight of Icarus: making human organs from PSCs with large animal chimeras. Cell Stem Cell. 2014;15:406–9. This review outlines several strategic technical approaches for generating transplantable human organs in large animals.CrossRefPubMedGoogle Scholar
- 5.Wade N. New prospects for growing human replacement organs in animals. New York Times. https://www.nytimes.com/2017/01/26/science/chimera-stemcells-organs.html?_r=0. Accessed 26 Jan 2017.
- 7.Streiffer R. At the edge of humanity: human stem cells, chimeras, and moral status. KIEJ. 2005;15:347–70.Google Scholar
- 12.United States National Institutes of Health. NIH research involving introduction of human pluripotent cells into non-human vertebrate animal pre-gastrulation embryos. 2015. https://grants.nih.gov/grants/guide/notice-files/NOT-OD-15-158.html.
- 16.National Research Council. Guide for the care and use of laboratory animals. Washington DC: National Academies Press; 1996.Google Scholar
- 17.Committee on Guidelines for Human Embryonic Stem Cell Research. Guidelines for human embryonic stem cell research. Washington DC: National Academies Press; 2005.Google Scholar
- 18.• International Society for Stem Cell Research, Guidelines for stem cell science and clinical translation 2016. http://www.isscr.org/home/publications/2016-guidelines. These scientific guidelines constitute the most current ethical standards for stem cell-based human-animal chimera research.
- 21.Kass LR. Life, liberty and the defense of dignity: the challenge for bioethics. San Francisco: Encounter Books; 2002.Google Scholar
- 22.Schulman A. Bioethics and the question of human dignity. In Human dignity and bioethics: essays commissioned by the President’s Council on Bioethics. 2008. Washington DC: www.bioethics.gov.