Therapeutic Applications for Adipose-Derived Stem Cells in Wound Healing and Tissue Engineering
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Purpose of Review
The use of adipose-derived stem cells (ASCs) has garnered recent interest for their accessibility and potential utility in wound healing applications. The purpose of this review is to provide an overview of developments within the last 5 years regarding therapeutic use of ASCs in wound healing applications.
Recent studies have demonstrated that ASCs do not exert the majority of their effects through differentiation, as previously believed. Rather, when they improve healing, it is via secreted factors that promote vascularization and control inflammation. New therapeutic approaches reflect this shift in belief.
ASC-based therapies can improve outcomes in the treatment of a variety of wound types. Questions about how to best implement ASCs in the clinical setting remain, and their answers will profoundly influence the utility and availability of ASC-based therapies.
KeywordsAdipose-derived stem cells Cytokine Pressure ulcers Scaffold Skin wound healing Stromal vascular fraction
The authors wish to thank Dr. Barbara Gawronska-Kozak, the staff of LaCell LLC, and the members of the Center for Stem Cell Research and Regenerative Medicine at Tulane University for their input and discussions during the preparation of this review article.
M.E.M., T.A.B., and J.M.G. researched data for the article and wrote the article. M.E.M., T.A.B., J.B., T.F., X.W., B.A.B, and J.M.G. made substantial contributions to discussions of the content and final revision of the manuscript. All authors reviewed and/or edited the manuscript before submission.
Compliance with Ethical Standards
Conflict of Interest
J.M.G. and X.W. are co-founders, co-owners and Chief Scientific Officer and Vice President for Research and Development, respectively, of LaCell LLC, a biotechnology company focusing on the clinical translation of stromal-cell and stem-cell science. J.M.G., X.W., and T.F. are the co-founders and co-owners of Obatala Sciences Inc., a biotechnology company focusing on humanized “fat on a chip” as a product for drug discovery where T.F. serves as the President and Chief Executive Officer.
J.M.G. is an inventor on multiple patents relating to adipose cells and products. X.W is about to submit a patent application from LaCell LLC on the use of adipose cells in therapy.
The other authors declare no competing interests.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as:• Of importance•• Of major importance
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