Corrosion Inhibition Study of Expired Acetazolamide on Mild Steel in Dilute Hydrochloric Acid Solution

  • L. P. Chaudhari
  • S. N. PatelEmail author


The corrosion inhibition properties of expired acetazolamide for mild steel in acidic solution were studied by gravimetric and Tafel polarization and Electrochemical Impedance spectroscopy. The inhibition efficiency evaluated by all methods was in good agreement with each other. Results suggest that the inhibition efficiency increases with increase in concentration and decreases with temperature. Inhibitor obeys Langmuir adsorption isotherm and shows inhibition efficiency up to 93% at 313 K for 500 ppm solution. Tafel polarization study suggests that it acts as mixed-type inhibitor. Thermodynamic parameters indicate that the adsorption process is spontaneous. Shifting of frequencies in FTIR spectra and SEM-EDX analysis confirms the adsorption of inhibitor on mild steel surface. Application of expired drug as corrosion inhibitor is useful to reduce environmental pollution and economically beneficial to pharmaceutical industries.

Graphical Abstract


Expired drug Mild steel Corrosion inhibitor SEM-EDX FTIR 



Mr Lakhan Prakash Chaudhari gratefully acknowledges the research grant provided by the North Maharashtra University Jalgaon under Vice Chancellor Research Motivational Scheme [VCRMS] (Grant No. NMU/11A/VCRMS/Budjet-2015/Science-8/65/2016). Authors are also thankful to Head of the U.I.C.T. department of North Maharashtra University, Jalgaon for SEM-EDX analysis facility.

Supplementary material

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Supplementary material 1 (PDF 125 KB)
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Supplementary material 2 (PDF 125 KB)


  1. 1.
    Doharea P, Chauhana DS, Sorourb AA, Quraishi MA (2017) DFT and experimental studies on the inhibition potentials of expired Tramadol drug on mild steel corrosion in hydrochloric acid. Mater Discov 9:30–41. CrossRefGoogle Scholar
  2. 2.
    Kamal C, Sethuraman M (2012) Spirulina platensis—A novel green inhibitor for acid corrosion of mild steel. Arab J Chem 5:155–161. CrossRefGoogle Scholar
  3. 3.
    Sherif ESM, Abbas AT, Gopi D, El-Shamy AM (2014) Corrosion and corrosion inhibition of high strength low alloy steel in 2.0 M sulfuric acid solutions by 3-amino-1,2,3-triazole as a corrosion inhibitor. J Chem. CrossRefGoogle Scholar
  4. 4.
    El-Etre AY, Abd El S, Wanees et al (2015) Comparison of the corrosion inhibition by drugs for the corrosion of Nickel in hydrochloric acid. J Am Sci. CrossRefGoogle Scholar
  5. 5.
    Ansari KR, Quraishi MA et al (2013) Electrochemical and thermodynamic investigation of diclofenac sodium drug as a potential corrosion inhibitor for mild steel in hydrochloric acid. Int J Electrochem Sci 8:12860–12873Google Scholar
  6. 6.
    Fouda S, El-Defrawy AM, El-Sherbeni MW (2013) Lornoxicam & tenoxicam drugs as green corrosion inhibitors for carbon steel in 1 M H2SO4 solution. J Electrochem Sci Technol 4(2):47–56. CrossRefGoogle Scholar
  7. 7.
    Naqvi I, Saleemi A, Naveed S (2011) Cefixime: a drug as efficient corrosion inhibitor for mild steel in acidic media. Electrochemical Thermodynamic Studies. Int J Electrochem Sci 6:146–161Google Scholar
  8. 8.
    Prasanna B, Matad et al (2014) Ketosulfone drug as a green corrosion inhibitor for mild steel in acidic medium. Ind Eng Chem Res 53:8436–8444. CrossRefGoogle Scholar
  9. 9.
    Mahmoud N. El-Haddad (2016) Inhibitive action and adsorption behavior of cefotaxime drug at copper/hydrochloric acid interface: electrochemical, surface and quantum chemical studies. RSC Adv 6:57844–57853. CrossRefGoogle Scholar
  10. 10.
    Kumar SH, Karthikeyan S (2013) Torsemide and furosemide as green inhibitors for the corrosion of mild steel in hydrochloric acid. Ind Eng Chem Res 52(22):7457–7469. CrossRefGoogle Scholar
  11. 11.
    Rajeswari V, Devarayan K, Viswanathamurthi P (2017) Expired pharmaceutical compounds as potential inhibitors for cast iron corrosion in acidic medium. Res Chem Intermed 43:3893. CrossRefGoogle Scholar
  12. 12.
    Gökhan G (2011) Drugs: a review of promising novel corrosion inhibitors. Corros Sci 53:3873–3898. CrossRefGoogle Scholar
  13. 13.
    El-Desoky AM et al (2015) Electrochemical and analytical study of the corrosion inhibitory behavior of expired pharmaceutical compounds for C-steel Corrosion. Int J Electrochem Sci 10:5112–5129Google Scholar
  14. 14.
    Shukla SK, Singh AK, Ebenso EE (2011) Pharmaceutically active compound as corrosion inhibitor for mild steel in acidic medium. Int J Electrochem Sci 6:4276–4285Google Scholar
  15. 15.
    Singh P, Chauhan DS, Srivastava K et al (2017) Expired atorvastatin drug as corrosion inhibitor for mild steelin hydrochloric acid solution. Int J Ind Chem 8:363. CrossRefGoogle Scholar
  16. 16.
    Geethamani P et al (2015) An expired non-toxic drug acts as corrosion inhibitor for mild steel in hydrochloric acid medium. IJCPS 3(1):1442–1448Google Scholar
  17. 17.
    Fouda AS, Etaiw SH, Wahba A (2015) Effect of acetazolamide drug as corrosion inhibitor for carbon steel in hydrochloric acid solution. Nat Sci 13(9):1–8Google Scholar
  18. 18.
    Yadav M, Sinha RR, Sarkar TK, Tiwari N (2015) Corrosion inhibition effect of pyrazole derivatives on mild steel in hydrochloric acid solution. J Adhes Sci Technol 29(16):1690–1713. CrossRefGoogle Scholar
  19. 19.
    Yadav M, Sinha RR, Kumar S, Sarkar TK (2015) Corrosion inhibition effect of spiropyrimidinethiones on mild steel in 15% HCl solution: insight from electrochemical and quantum studies. RSC Adv 5:70832–70848. CrossRefGoogle Scholar
  20. 20.
    Akbarzadeh E, Ibrahim MNM, Rahim AA (2011) Corrosion inhibition of mild steel in near neutral solution by kraft and soda lignins extracted from oil palm empty fruit bunch. Int J Electrochem Sci 6:5396–5416Google Scholar
  21. 21.
    Thanapackiam P et al (2016) Electrochemical evaluation of inhibition efficiency of ciprofloxacin on the corrosion of copper in acid media. Mater Chem Phys. CrossRefGoogle Scholar
  22. 22.
    Verma C, Quraishi MA, Ebenso EE et al (2018) A green and sustainable approach for mild steel acidic corrosion inhibition using leaves extract: experimental and DFT studies. J Bio Tribo Corros 4:33. CrossRefGoogle Scholar
  23. 23.
    Saman Zehra M, Mobin JA, Parveen M (2018) Assessment of glycine derivative N-benzylidine-2((2-oxo-2-(10H-phenothiazine-10yl)ethyl)amino) acetohydrazide as inhibitor for mild steel corrosion in 1 M HCl solution: electrochemical and theoretical approach. J Adhes Sci Technol 32(3):317–342. CrossRefGoogle Scholar
  24. 24.
    Eddy NO, Ebenso EE (2010) Adsorption and quantum chemical studies on cloxacillin and halides for the corrosion of mild steel in acidic medium. Int J Electrochem Sci 5:731–750Google Scholar
  25. 25.
    Emeka E, Oguzie (2008) Evaluation of the inhibitive effect of some plant extracts on the acid corrosion of mild steel. Corros Sci 50:2993–2998. CrossRefGoogle Scholar
  26. 26.
    Nathiya RS, Perumal S, Murugesan V et al (2018) Expired drugs: environmentally safe inhibitors for aluminium corrosion in 1 M H2SO4. J Bio Tribo Corros 4:4. CrossRefGoogle Scholar
  27. 27.
    de Souza FS, Spinelli A (2009) Caffeic acid as a green corrosion inhibitor for mild steel, Corros Sci 51:642–649, CrossRefGoogle Scholar
  28. 28.
    Karthik G, Sundaravadivelu M (2016) Studies on the inhibition of mild steel corrosion in hydrochloric acid solution by atenolol drug. Egypt J Pet 25:183–191. CrossRefGoogle Scholar
  29. 29.
    Praveen BM, Prasanna BM, Hebbar N et al (2018) Experimental and theoretical studies on inhibition effect of the praziquantel on mild steel corrosion in 1 M HCl. J Bio Tribo Corros 4:21. CrossRefGoogle Scholar
  30. 30.
    Ansari KR, Ramkumar S, Nalini D, Quraishi MA, Slawin AMZ (2016) Studies on adsorption and corrosion inhibitive properties of quinoline derivatives on N80 steel in 15% hydrochloric acid. Cogent Chem 2:1. CrossRefGoogle Scholar
  31. 31.
    Shukla SK, Singh AK, Ahamad I, Quraishi MA (2009) Streptomycin: a commercially available drug as corrosion inhibitor for mild steel in hydrochloric acid solution. Mater Lett 63:819–822. CrossRefGoogle Scholar
  32. 32.
    Shukla SK, Ebenso EE (2011) Corrosion inhibition, adsorption behavior and thermodynamic properties of streptomycin on mild steel in hydrochloric acid medium. Int J Electrochem Sci 6:3277–3291Google Scholar
  33. 33.
    Vinutha MR, Venkatesha TV, Nagaraja C (2018) Anticorrosive ability of electrochemically synthesized 2,2′-disulfanediyldianiline for mild steel corrosion: electrochemical and thermodynamic studies. Int J Ind Chem 9:185. CrossRefGoogle Scholar
  34. 34.
    Ameh PO, Sani UM (2016) Cefuroxime axetil: a commercially available drug as corrosion inhibitor for aluminum in hydrochloric acid solution. Portugaliae Electrochim Acta 34(2):131–141. CrossRefGoogle Scholar
  35. 35.
    Nnaji NJ, Obi-Egbedia NO, Nnabugwu MA (2012) Kinetics and thermodynamics of aluminium corrosion inhibition by anthocleista djalonensis leaf extract in hydrochloric acid solution. Int J Chem Sci 10(1):182–194Google Scholar
  36. 36.
    Umoren SA (2016) Biomaterials for corrosion protection: evaluation of mustard seed extract as eco-friendly corrosion inhibitor for X60 steel in acid media. J Adhes Sci Technol 30:17,1858–1879. CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.PG and Research Department of ChemistryS.P.D.M. CollegeShirpur, Dist. DhuleIndia

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