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Current Sleep Medicine Reports

, Volume 5, Issue 1, pp 1–12 | Cite as

A Human Neuroimaging Perspective on Sleep in Normative and Pathological Ageing

  • Nathan CrossEmail author
  • Nadia Gosselin
  • Thien Thanh Dang-VuEmail author
Sleep and Aging (A Spira, Section Editor)
  • 125 Downloads
Part of the following topical collections:
  1. Topical Collection on Sleep and Aging

Abstract

Purpose of Review

There is a growing body of evidence detailing how phenotypic changes in sleep with increasing age are not only associated with declining functions, but how sleep disorders may also indicate underlying pathology, particularly neurodegenerative diseases. As sleep is implicated in maintenance and protective processes within the brain, poor sleep quality may also contribute to neurodegenerative processes. This review details the neuroimaging literature surrounding age-related changes in sleep and outlines how sleep disorders are related to changes in neural integrity with advancing age.

Recent Findings

Sleep disturbance can increase the production of amyloid-β, an age-related peptide associated with Alzheimer’s disease pathology. Obstructive sleep apnoea has been implicated in exacerbating both changes that occur with both normative ageing and neurodegenerative processes in dementia. While conversion rates may differ, recent evidence suggests all patients with REM sleep behaviour disorder may eventually develop an α-synucleinopathy-related neurodegenerative disease.

Summary

Sleep is a complex behaviour and encapsulates many important processes for overall brain health. The relationship between changing features of sleep with age and neurodegeneration is highly complicated; however, human neuroimaging research provides great potential to understand these multifaceted connections.

Keywords

Sleep disorders Insomnia Obstructive sleep apnoea REM sleep behaviour disorder Neurodegenerative disease Dementia 

Notes

Compliance with Ethical Standards

Conflict of Interest

Nathan Cross, Nadia Gosselin and Thien-Thanh Dang-Vu each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Institut Universitaire de Gériatrie de Montréal and CRIUGMCIUSSS du Centre-Sud-de-l’Île-de-MontréalMontrealCanada
  2. 2.PERFORM Centre, Center for Studies in Behavioral Neurobiology, Department of Health, Kinesiology and Applied PhysiologyConcordia UniversityMontrealCanada
  3. 3.Center for Advanced Research in Sleep Medicine, Hopital du Sacre-Coeur de MontrealCIUSSS du Nord-de-l’Île-de-MontréalMontrealCanada
  4. 4.Department of PsychologyUniversité de MontréalMontrealCanada

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