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Current Sleep Medicine Reports

, Volume 4, Issue 3, pp 231–242 | Cite as

OSA Endotypes: What Are They and What Are Their Potential Clinical Implications?

  • Christopher N. Schmickl
  • Robert L. Owens
  • Bradley A. Edwards
  • Atul Malhotra
Sleep Related Breathing Disorders (L Kheirandish-Gozal, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Sleep Related Breathing Disorders

Abstract

Purpose of the Review

To review critically the different mechanisms, or endotypes, causing obstructive sleep apnea (OSA) in individual patients, and their potential implications for management.

Recent Findings

Currently, at least four underlying mechanisms that contribute to OSA have been identified, namely a compromised upper airway anatomy, a poor pharyngeal muscle responsiveness, respiratory control instability (high loop gain), and a low arousal threshold (wake up too easily); the relative contributions of these four traits in an individual form their endotype. Endotypes provide therapeutic targets that may facilitate development of novel therapies, can predict treatment response to non-CPAP therapies, and may explain clinical phenotypes. Endotyping is currently restricted to specialized research laboratories, but newer methods relying on standard polysomnography may soon allow routine assessment of endotypes as part of clinical practice.

Summary

Endotyping promises to transform the current one-size fits-all OSA management into an individualized precision medicine approach in the future.

Keywords

Obstructive sleep apnea Endotype Phenotype Pathogenesis Mechanisms Management 

Notes

Compliance with Ethical Standards

Conflict of Interest

Christopher N. Schmickl declares no conflicts of interest.

Robert L. Owens reports personal fees from Novartis, personal fees from ResMed, personal fees from Itamar.

Bradley A. Edwards grants from Heart Foundation of Australia.

Atul Malhotra relinquished all outside personal income in 2012 as an Officer of the American Thoracic Society. Resmed provided a philanthropic donation to the UC San Diego in support of a sleep center.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Grant Support

Robert L. Owens is supported by NHLBI R01 HL142114–01. Bradley A. Edwards is supported by a Heart Foundation of Australia Future Leader Fellowship (101167).

Supplementary material

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ESM 1 (DOCX 2328 kb)
40675_2018_121_MOESM2_ESM.docx (1.7 mb)
ESM 2 (DOCX 1715 kb)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Christopher N. Schmickl
    • 1
  • Robert L. Owens
    • 2
  • Bradley A. Edwards
    • 3
    • 4
  • Atul Malhotra
    • 2
  1. 1.Division of Pulmonary, Critical Care and Sleep MedicineBeth Israel Deaconess Medical CenterBostonUSA
  2. 2.Division of Pulmonary, Critical Care and Sleep MedicineUC San DiegoLa JollaUSA
  3. 3.Sleep and Circadian Medicine Laboratory, Department of PhysiologyMonash UniversityMelbourneAustralia
  4. 4.School of Psychological Sciences and Monash Institute of Cognitive and Clinical NeurosciencesMonash UniversityMelbourneAustralia

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