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Update on ANCA-associated vasculitis: from biomarkers to therapy

  • Martina Tedesco
  • Maurizio Gallieni
  • Francesca Pellegata
  • Mario Cozzolino
  • Federico AlbericiEmail author
Review

Abstract

ANCA-associated vasculitis (AAV) are the prototype of a disease characterised by the presence of a biomarker; ANCA positivity in fact is recorded in 90% of cases of GPA and MPA. The role of ANCA in the management of AAV ranges from diagnostic to prognostic purposes with also therapeutic implications. Changes in clinical practice with the increased use of rituximab have drawn attention to B-cells as a biomarker able to contribute to patient management. Cytokines and other circulating factors, although still at a research stage, may represent future biomarkers of interest or even therapeutic options. From the point of view of renal involvement in AAV, proteinuria and microhematuria are still the biomarkers employed in everyday clinical practice with a proposed role for emerging ones (MCP1, CD163 and CD25). The aim of this review is to discuss the role of well-known biomarkers in everyday clinical management of AAV patients as well as future perspectives for those that are still at a research stage with attention to therapeutic implications.

Keywords

Vasculitis ANCA Biomarkers B-cells Rituximab 

Notes

Compliance with ethical standards

Conflict of interest

MT, MG, FP, MC and FA have nothing to disclose. The Authors declare no conflict of interest.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

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Copyright information

© Italian Society of Nephrology 2019

Authors and Affiliations

  1. 1.Nephrology Unit and Immunology ClinicASST Santi Paolo e CarloMilanItaly
  2. 2.ASST Fatebenefratelli SaccoMilanItaly
  3. 3.Dipartimento di Scienze Biomediche e Cliniche “L. Sacco”University of MilanoMilanItaly
  4. 4.Dipartimento di Scienze della SaluteUniversity of MilanoMilanItaly

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