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L'Endocrinologo

, Volume 20, Issue 5, pp 303–306 | Cite as

Il recettore del calcio nella patologia paratiroidea

  • Simona Borsari
  • Tommaso Biagioni
  • Filomena CetaniEmail author
GENETICA IN ENDOCRINOLOGIA
  • 40 Downloads

Introduzione

Il recettore del calcio (CaSR) è un recettore transmembrana, appartenente alla sottofamiglia C dei recettori accoppiati a proteine G, espresso principalmente nelle cellule paratiroidee e nel rene (Fig.  1). Il CaSR ricopre un ruolo cruciale nel rilevare e rispondere a piccole oscillazioni dei livelli di calcio sierico, con lo scopo di mantenerne la concentrazione in un ristretto intervallo fisiologico (1,13–1,32 mM/L). La sua attivazione, indotta dal calcio extracellulare, modula, attraverso le vie di trasduzione del segnale intracellulare, la secrezione di paratormone (PTH) e l’escrezione renale di calcio [ 1].

Notes

Conflitto di interesse

Gli autori Simona Borsari, Tommaso Biagioni e Filomena Cetani dichiarano di non avere conflitti di interesse.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi su animali.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Simona Borsari
    • 1
  • Tommaso Biagioni
    • 1
  • Filomena Cetani
    • 2
    Email author
  1. 1.Dipartimento di Medicina Clinica e SperimentaleUniversità di PisaPisaItalia
  2. 2.Azienda Ospedaliero-Universitaria PisanaPisaItalia

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