Advertisement

L'Endocrinologo

, Volume 19, Issue 3, pp 136–141 | Cite as

Valutazione della funzione testicolare in età pediatrica e prepuberale

  • Rosita A. Condorelli
  • Rossella Cannarella
  • Aldo E. Calogero
  • Sandro La Vignera
Rassegna
  • 41 Downloads

Sommario

In età pediatrica e prepuberale le cellule del Sertoli sono attivamente proliferanti e metabolicamente attive. I livelli sierici di ormone anti-mülleriano (AMH) e di inibina B, entrambi prodotti dalle cellule del Sertoli, rappresentano dei marcatori della funzione testicolare particolarmente utili. Già in età pediatrica e prepuberale, infatti, essi presentano livelli alterati in numerose patologie andrologiche. In età pediatrica e prepuberale, AMH e inibina B, insieme all’ecometria testicolare, potrebbero essere utilizzati per la diagnosi precoce delle disfunzioni testicolari.

Parole chiave

AMH Inibina B Cellule di Sertoli Testicolo 

Notes

Conflitto di interesse

Gli autori Rosita A. Condorelli, Rossella Cannarella, Aldo E. Calogero e Sandro La Vignera dichiarano di non avere conflitti di interesse.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

Supplementary material

40619_2018_446_MOESM1_ESM.doc (28 kb)
(DOC 29 kB)
40619_2018_446_MOESM2_ESM.doc (26 kb)
(DOC 27 kB)

Bibliografia

  1. 1.
    Isidori AM, Balercia G, Calogero AE et al. (2015) Outcomes of androgen replacement therapy in adult male hypogonadism: recommendations from the Italian society of endocrinology. J Endocrinol Invest 38:103–112 CrossRefPubMedGoogle Scholar
  2. 2.
    Condorelli R, Calogero AE, La Vignera S (2013) Relationship between testicular volume and conventional or nonconventional sperm parameters. Int J Endocrinol 2013:145792 CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Edelsztein NY, Grinspon RP, Schteingart HF et al. (2016) Anti-Müllerian hormone as a marker of steroid and gonadotropin action in the testis of children and adolescents with disorders of the gonadal axis. Int J Pediatr Endocrinol 2016:20 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Nistal M, Paniagua R, González-Peramato P et al. (2015) Perspectives in pediatric pathology, chapter 1. Normal development of testicular structures: from the bipotential gonad to the fetal testis. Pediatr Dev Pathol 18(2):88–102 CrossRefPubMedGoogle Scholar
  5. 5.
    Rey RA, Musse M, Venara M et al. (2009) Ontogeny of the androgen receptor expression in the fetal and postnatal testis: its relevance on Sertoli cell maturation and the onset of adult spermatogenesis. Microsc Res Tech 72(11):787–795 CrossRefPubMedGoogle Scholar
  6. 6.
    Cannarella R, Condorelli RA, La Vignera S et al. (2018) Effects of the insulin-like growth factor system on testicular differentiation and function: a review of the literature. Andrology 6(1):3–9 CrossRefPubMedGoogle Scholar
  7. 7.
    Cimino I, Casoni F, Liu X et al. (2016) Novel role for anti-Müllerian hormone in the regulation of GnRH neuron excitability and hormone secretion. Nat Commun 7:10055 CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Iliadou PK, Tsametis C, Kaprara A et al. (2015) The Sertoli cell: Novel clinical potentiality. Hormones (Athens) 14(4):504–514 CrossRefGoogle Scholar
  9. 9.
    Cao SS, Shan XO, Hu YY (2016) Impact of unilateral cryptorchidism on the levels of serum anti-Müllerian hormone and inhibin B. Zhonghua Nan Ke Xue 22(9):805–808 PubMedGoogle Scholar
  10. 10.
    Varimo T, Miettinen PJ, Känsäkoski J et al. (2017) Congenital hypogonadotropic hypogonadism, functional hypogonadotropism or constitutional delay of growth and puberty? An analysis of a large patient series from a single Tertiary center. Hum Reprod 32(1):147–153 PubMedGoogle Scholar
  11. 11.
    Goede J, Hack WW, Sijstermans K et al. (2011) Normative values for testicular volume measured by ultrasonography in a normal population from infancy to adolescence. Horm Res Paediatr 76(1):56–64 CrossRefPubMedGoogle Scholar
  12. 12.
    Kola B (2017) Pediatric testicular microlithiasis: to refer or not to refer? Glob Pediatr Health 4:2333794X17731854 PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rosita A. Condorelli
    • 1
  • Rossella Cannarella
    • 1
  • Aldo E. Calogero
    • 1
  • Sandro La Vignera
    • 1
  1. 1.Dipartimento di Medicina Clinica e SperimentaleUniversità di CataniaCataniaItalia

Personalised recommendations