Circulating leptin is associated with serum uric acid level and its tubular reabsorption in a sample of adult middle-aged men

  • L. D’EliaEmail author
  • A. Giaquinto
  • F. P. Cappuccio
  • R. Iacone
  • O. Russo
  • P. Strazzullo
  • F. GallettiEmail author
Original Article



Leptin is associated with cardiovascular risk factors (e.g. hypertension, insulin resistance, kidney disease and excess body weight). Experimental studies showed that leptin might affect serum uric acid, by modulation of the uric acid excretion. However, there are few observational data on the relationship between leptin and uric acid in the general population. Therefore, the aim of the present study was to evaluate the relationship between leptin and uric acid and its excretion in a large middle-aged male general population.


A sample of 930 adult male individuals (mean age: 52 years) without therapy for high uric acid was included in the analysis (the Olivetti Heart Study).


Uric acid was significantly and positively associated with blood pressure, BMI, waist circumference, insulin resistance, C-reactive protein and leptin (p < 0.01), while inversely with renal function (p = 0.01). The multivariate analysis confirmed the association between leptin and uric acid after adjustment for potential confounders (p < 0.01). After division for adiposity, this trend was confirmed separately for normal weight and excess body weight participants. Moreover, leptin was inversely associated with excretion of uric acid (p < 0.01), also in multivariate analysis (p = 0.03).


The results of this study indicate a positive association between circulating leptin levels and uric acid, independently of potential confounders, both in normal and excess body weight men. Furthermore, an inverse association between leptin and uric acid excretion was detected.


Cardiovascular risk Uric acid Uric acid excretion Adipocytokines Adipokines Leptin 




Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Ethics Committee of “Federico II” University in Naples.

Informed consent

All participants provided their informed written consent to participate.


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Copyright information

© Italian Society of Endocrinology (SIE) 2019

Authors and Affiliations

  1. 1.Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension“Federico II” University of Naples Medical SchoolNaplesItaly
  2. 2.World Health Organization Collaborating Centre for NutritionUniversity of WarwickCoventryUK
  3. 3.Division of Health Sciences, Warwick Medical SchoolUniversity of WarwickCoventryUK

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