Extracellular Vesicles: How to Shuttle the Metastatic Programme

  • Alfredo CapparielloEmail author
  • Nadia Rucci
Molecular Biology of Bone Metastasis (H Taipaleenmäki and M Capulli, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Molecular Biology of Bone Metastasis


Purpose of Review

This review has the meaning of providing a state-of-the-art in the role of tumour-derived EVs in educating the host microenvironment during the metastatic process.

Recent Findings

Extracellular vesicles (EVs) now represent another piece in the complex puzzle that is tumorigenesis and metastasis. The indication that EVs are more than just a way for cells to dispose of waste and actually work as active and dynamic structures packaging molecular signals arose in the late ‘60s, when EV-like structures were involved in the function of coagulation. Since then, a huge amount of information has been collected, and we are now aware that EVs are crucially involved in paracrine and distant cell-cell communication under physiologic and pathologic conditions, such as cancer metastasis to bone.


We will focus on the EV-mediated mechanisms regulating bone homeostasis, and we will describe the way these mechanisms are dysregulated by osteotropic cancer cell-derived EVs.


Tumour Extracellular vesicles Metastasis Bone 


Funding Information

This review was supported by the grant Ricerca Finalizzata #RF-2013-02357539 Id.E13C17000100005 of the “Ministero della Salute e della Ricerca Scientifica” for salary to AC and the grant # IG 2015 Id.16826 of the “Associazione Italiana per la Ricerca sul Cancro” to NR.

Compliance with Ethical Standards

Conflict of Interest

Alfredo Cappariello reports grants from the Italian Ministry of Health. Dr. Cappariello has a patent pending (10201500024334). Ndia Rucci reports grants from the Italian Association for Cancer Research.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Authors and Affiliations

  1. 1.Research Laboratories, Oncohematology DepartmentIRCCS Bambino Gesù Children’s HospitalRomeItaly
  2. 2.Department of Biotechnological and Applied Clinical SciencesUniversity of L’AquilaL’AquilaItaly

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