Current Clinical Microbiology Reports

, Volume 6, Issue 1, pp 1–9 | Cite as

Beyond the NEC: Modulation of Herpes Simplex Virus Nuclear Egress by Viral and Cellular Components

  • Bruce W. BanfieldEmail author
Virology (A Nicola, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Virology


Purpose of Review

Herpesvirus virions are complex molecular machines that, like most viruses, must be stable in the extracellular environment yet disassemble readily upon receipt of the appropriate molecular cues. While we have learned much about the assembly and composition of these fascinating particles, many central questions remain unanswered.

Recent Findings

This review focuses on an early stage in herpesvirus assembly called nuclear egress whereby viral DNA genomes packaged within an icosahedral protein capsid are translocated from the nucleoplasm across both the inner and outer nuclear membranes to reach the cytoplasm where the final stages of virion maturation take place.


Here, I provide an overview of our current understanding of herpes simplex virus nuclear egress, the hurdles that the virus must overcome during nuclear egress, and discuss the literature pointing to the regulation and facilitation of this process by viral and cellular components.


Herpes simplex virus Virion assembly Nuclear egress 



I thank Jie Gao for the helpful discussions and Renée Finnen for the helpful discussions and critical reading of the manuscript. Work in our laboratory is supported by the Canadian Institutes of Health Research operating grant 93804, Natural Sciences and Engineering Research Council of Canada Discovery grant 418719, and Canada Foundation for Innovation award 16389. I apologize to my many colleagues whose work could not be cited because of length restrictions.

Compliance with Ethical Standards

Conflict of Interest

The author declares that he has no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Biomedical and Molecular SciencesQueen’s UniversityKingstonCanada

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