Current Status of Noninvasive Prenatal Testing and Counselling Considerations: An Indian Perspective

  • James D. MassaEmail author
  • Veronica Arora
  • Meenakshi Lallar
  • Sunita Bijarnia
  • Ratna Dua Puri
  • Ishwar C. VermaEmail author
Review Article


Uptake of noninvasive prenatal testing (NIPT) is rapidly expanding around the world. Here, we provide an overview of the current global state of NIPT, describe the expansion of the test menu, highlight alternative prenatal test service delivery, and discuss NIPT counseling considerations. We also provide a perspective on utilisation of NIPT in India, which has unique challenges for implementing NIPT given its large population, vast territory, and diverse ethnic groups. The barriers to implementation of NIPT in India are also discussed. Current recommendations regarding use of NIPT made by professional societies vary in different regions and such recommendations for NIPT in India will be helpful to provide general guidance to the health care providers, but will likely require modifications for implementation in India.


Noninvasive prenatal testing (NIPT) Noninvasive prenatal screening (NIPS) Cell-free DNA (cfDNA) India Counselling Prenatal Diagnosis Techniques Act Limitations Guidelines 



The authors would like to thank Kristine Jinnett, Sucheta Bhatt, Christin Coffeen, and Kirsten Curnow (Illumina, Inc.) for their assistance in the preparation of the manuscript.

Compliance with Ethical Standards

Conflict of interest

JM is an employee of Illumina, Inc. VA, ML, SB, RDP and ICV are employees of Institute of Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi.


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Copyright information

© Society of Fetal Medicine 2019

Authors and Affiliations

  • James D. Massa
    • 1
    Email author
  • Veronica Arora
    • 2
  • Meenakshi Lallar
    • 2
  • Sunita Bijarnia
    • 2
  • Ratna Dua Puri
    • 2
  • Ishwar C. Verma
    • 2
    Email author
  1. 1.Medical AffairsIllumina, Inc.San DiegoUSA
  2. 2.Institute of Medical Genetics and GenomicsSir Ganga Ram HospitalNew DelhiIndia

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