Journal of Fetal Medicine

, Volume 5, Issue 4, pp 209–212 | Cite as

Diagnosis of Acrania Before 11 Weeks

  • Deval ShahEmail author
Original Article


To review embryonic skull shape and brain anatomy by sonography during late embryonic and early fetal periods. We examined embryos/fetuses of 8–11 weeks between March 2015 and February 2018, the period corresponds to CRL 16–44 mm and also corresponds to late embryonic and early fetal periods by transvaginal and transabdominal sonography. We assessed shape of the skull and intracranial brain vesicles. Additionally, embryonic brain anatomy was also assessed by three-dimensional ultrasound. We found 12 abnormal cases, 5 cases between CRL 16–30 mm and 7 cases between CRL 31–44 mm. We followed all cases between 11 and 13 weeks and confirmed acrania with loss of variable amount of brain tissues. Acrania–Exencephaly–Anencephaly sequence can be diagnosed before 11 weeks. Sonographer should be familiar and proper knowledge of brain embryology and anatomy is key to diagnose.


Acrania Exencephaly Anencephaly Brain vesicles 



Dr Mayank Chaudhry, Fetal medicine expert, Mayflower hospital, Ahmedabad.

Compliance with Ethical Standards

Conflict of interest

The author declares that he has no conflict of interest.


  1. 1.
    Donkelaar H, Lammens M, Hori A. Clinical neuroembryology: development and developmental disorders of the human central nervous system. 2nd ed. Berlin: Springer; 2014. p. 12–4.Google Scholar
  2. 2.
    Kandasamy V, Subramanian M, Sivaanandam R. A study on the incidence of neural tube defects in a tertiary care hospital over a period of five years. J Clin Diagn Rese. 2015;9(7):QC01–4.Google Scholar
  3. 3.
    Menasinkai Sharada B. A study of neural tube defects. J Anat Soc India. 2010;59(2):162–7.CrossRefGoogle Scholar
  4. 4.
    Chatzipapas IK, Whitow BJ, Economides DL. The ‘Mickey Mouse’ sign and the diagnosis of anencephaly in early pregnancy. Ultrasound Obstet Gynecol. 1999;13:196–9.CrossRefPubMedGoogle Scholar
  5. 5.
    Tanaka H, Hata T. Intrauterine sonographic measurement of the embryonic brain mantle. Ultrasound Obstet Gynecol. 2009;34:47–51.CrossRefPubMedGoogle Scholar
  6. 6.
    Pooh RK, Kurjak A. 3D/4D sonography moved prenatal diagnosis of fetal anomalies from the second to the first trimester of pregnancy. J Matern Fetal Neonatal Med. 2012;25:433–55.CrossRefPubMedGoogle Scholar
  7. 7.
    Miguelez J, Hisaba W, Boute T. Case report: diagnosis of 3 cases of anencephaly/exencephaly at 8–10 weeks. Ultrasound Obstet Gynecol. 2014;44:207.CrossRefGoogle Scholar

Copyright information

© Society of Fetal Medicine 2018

Authors and Affiliations

  1. 1.Astha Hospital and Fetal Medicine CenterDeesaIndia

Personalised recommendations