Current Treatment Options in Allergy

, Volume 6, Issue 3, pp 175–188 | Cite as

Treatment of Chronic Spontaneous Urticaria: a Focused Update in Omalizumab

  • Whitney A. BlackwellEmail author
  • David A. Khan
Urticaria and Atopic Dermatitis (M Furue and T Nakahara, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Urticaria and Atopic Dermatitis


Purpose of review

Chronic spontaneous urticaria (CSU) is a common disease in the general population that causes significant effects on quality of life and a financial burden on the health care system. Guidelines are essential to assure patients are being managed appropriately, although given the rigor to develop these reviews they are not as up to date as cutting-edge scientific evidence. This review details the most recent phase II, III, and IV clinical trials that have been published since the development of the US practice parameters.

Recent findings

Phase II, III, and IV clinical trials, ASTERIA I, POLARIS, X-ACT, MoA, and CTEND-CIU, demonstrate safety, long-term efficacy, and improvement in patient’s quality of life by decreasing disease-burdened days and severity of disease in comparison with placebo, as well as transcriptional level changes in gene expression with omalizumab use. Data is emerging regarding efficacy in inducible urticarias, predictors of response, and optimal methods for discontinuation of omalizumab.


Optimal treatment of CSU should be based on recent practice parameters and guidelines. Recent evidence supports the use of omalizumab in antihistamine refractory urticaria patients, but the mechanism for its effect, identification of biomarkers to predict response to therapy, optimal duration, and adjustments in dosing all require additional investigation.


Omalizumab Urticaria Treatment Adverse effect Angioedema 


Compliance with Ethical Standards

Conflict of Interest

Whitney A. Blackwell declares that she has no conflict of interest.

David A. Khan declares that he has no conflict of interest.

Human and Nnimal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Internal Medicine, Division of Allergy and ImmunologyUniversity of Texas Southwestern Medical CenterDallasUSA

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