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Evidence-Based Medicine and Real-World Data in Allergen Immunotherapy Today and in the Future: Quality or Quantity?

  • Moisés A. CalderonEmail author
  • Pilar Rico Nieto
  • Pascal Demoly
Specific Immunotherapy (L Cox, Section Editor)
  • 7 Downloads
Part of the following topical collections:
  1. Topical Collection on Specific Immunotherapy

Abstract

Purpose of the review

Data obtained from controlled clinical trials remains the gold standard for the evaluation of treatment efficacy and safety. This information is used in systematic reviews and meta-analysis providing data for evidence-based medicine (EBM) statements and conclusions which are preferred by regulatory and academic groups when decisions and recommendations need to be given.

Recent findings:

The quantity and diversity of real-world data (RWD) have been increasing exponentially as technology and integrated electronic medical records have made this information increasingly accessible and useful for outcomes research and regulatory purposes.

There are increasing interest and potential for converting RWD into real-world evidence that, through careful analysis and interpretation, can be used to inform healthcare decision-making.

Summary

In this article, we present a concise summary of the literature about the role of EBM and RWD in allergen immunotherapy. We are aiming to evaluate their influence on current and future decisions for good clinical practice parameter recommendations.

Keywords

Evidence-based medicine Real-world data Allergen immunotherapy 

Notes

Compliance with ethical standards

Conflict of interest

Dr. Demoly reports personal fees from ALK, personal fees from StallergènesGreer, personal fees from Iqvia, personal fees from Chiesi, personal fees from AstraZeneca, personal fees from ThermoFisherScientific, personal fees from Sanofi-Regeneron, personal fees from Ménarini, personal fees from Bausch&Lomb and personal fees from Novartis, outside the submitted work.

Prof Dr. Moisés A. Calderon has received an honorarium as speaker from AKL-Abello, AKL-USA, ALK-Canda, Stallergenes Greer and HAL-Allergy and as an advisory board member from ALK-Abello, Stallergenes Greer, HAL-Allergy and ASIT-Biotech.

Dr. Rico has nothing to disclose.

Human and animal rights and informed consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Moisés A. Calderon
    • 1
    Email author
  • Pilar Rico Nieto
    • 2
  • Pascal Demoly
    • 3
    • 4
  1. 1.Section of Allergy and Clinical ImmunologyImperial College LondonLondonUK
  2. 2.Institute of Applied Molecular Medicine, Department of Basic Medical Sciences, Faculty of MedicineSan Pablo CEU UniversityMadridSpain
  3. 3.Department of Pulmonology, Division of Allergy, Hôpital Arnaud de VilleneuveUniversity Hospital of MontpellierMontpellierFrance
  4. 4.Equipe EPAR – IPLESPUMR-S 1136 INSERM-Sorbonne UniversitéParisFrance

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