Arterial stiffness and multiple organ damage: a longitudinal study in population

  • Angelo ScuteriEmail author
  • Cristopher H. Morrell
  • Danilo Alunni Fegatelli
  • Edoardo Fiorillo
  • Alessandro Delitala
  • Marco Orru’
  • Michele Marongiu
  • David Schlessinger
  • Francesco Cucca
Original Article



Previous cross-sectional observation identified arterial aging, indexed as pulse-wave velocity (PWV), as a key determinant of the simultaneous multiple organ damage (heart, carotid artery, and kidney). The aim of the present cohort study is to investigate trajectories of repeated measures of PWV and traditional CV risk factors in subjects who eventually presented clinical evidence of multiple organ damage in the SardiNIA study.

Methods and results

Organ damage was measured in the heart (left ventricular hypertrophy, LVH), the common carotid artery (intima–media thickness > 0.9 mm and/or plaque), and the kidney (eGFR < 60 ml/min/1.73 m2) of 2130 men and women of a broad age range participating the SardiNIA study. SHATS was defined as the simultaneous occurrence of all the three-organ damages. Trajectory in traditional CV risk factors and PWV was analyzed retrospectively (four observations over 9 years) according to the number of organ damage (from 0 to 3). Compared to subjects with no organ damage, after controlling for traditional CV risk factors, each 1 m/s increase in baseline PWV was accompanied by a 93% higher odds of developing SHATS; and each 1 cm/s (0.01 m/s) annual increase in PWV by a 31% greater odds of developing SHATS.


Arterial stiffness, a proxy of arterial aging that can be measured clinically as PWV, is an integrated predictive marker of multiple age-associated organ damage recognized as clinical diseases.


Arterial stiffness Pulse-wave velocity Left ventricular hypertrophy Chronic kidney disease Multiple organ damage Longitudinal study 



This research was supported in part by the Intramural Research Program of the US National Institutes of Health, National Institute on Aging (Grant No. HHSN271201600005C).

Compliance with ethical standards

Conflict of interest

No author has to disclose any conflict of interest that could have direct or potential influence or impart bias on the work.

Statement of human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

40520_2019_1260_MOESM1_ESM.docx (175 kb)
Supplementary material 1 (DOCX 175 kb)


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Copyright information

© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply  2019

Authors and Affiliations

  • Angelo Scuteri
    • 1
    Email author
  • Cristopher H. Morrell
    • 2
    • 3
  • Danilo Alunni Fegatelli
    • 4
  • Edoardo Fiorillo
    • 5
  • Alessandro Delitala
    • 5
  • Marco Orru’
    • 5
  • Michele Marongiu
    • 5
  • David Schlessinger
    • 6
  • Francesco Cucca
    • 7
  1. 1.Department of Medical, Surgical, and Experimental SciencesUniversity of SassariSassariItaly
  2. 2.Laboratory of Cardiovascular Sciences, National Institute on Aging Intramural Research ProgramNIHBaltimoreUSA
  3. 3.Loyola University MarylandBaltimoreUSA
  4. 4.Department of Public Health and Infectious DiseaseUniversity “La Sapienza”RomeItaly
  5. 5.Istituto di Ricerca Genetica e Biomedica (IRGB)Consiglio Nazionale delle Ricerche (CNR)LanuseiItaly
  6. 6.Laboratory of Genetics, National Institute on Aging Intramural Research ProgramNIHBaltimoreUSA
  7. 7.Istituto di Ricerca Genetica e Biomedica (IRGB)Consiglio Nazionale delle Ricerche (CNR)CagliariItaly

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