Aging Clinical and Experimental Research

, Volume 31, Issue 12, pp 1775–1781 | Cite as

The nutritional risk and short-, medium- and long-term mortality of hospitalized patients with atrial fibrillation

  • Jesús Díez-ManglanoEmail author
  • Carolina Clemente-Sarasa
Original Article



To determine the association between the level of nutritional risk and the mortality of hospitalized patients with atrial fibrillation.


In a prospective cohort study, we included patients hospitalized with atrial fibrillation in an internal medicine department in 2007. We calculated the nutritional risk with the Controlling Nutritional Status (CONUT) score and conducted a 10-year follow-up. To determine the variables associated with mortality in the short (3 months), medium (1 year) and long term (10 years), we constructed a Cox proportional hazards regression model and calculated the Kaplan–Meier survival curves.


The study included 282 patients with a mean (SD) age of 81.2 (7.9) years. The mean CONUT score was 4.7 (2.8) points. Thirty-six patients had zero nutritional risk, 110 had a low risk, 106 had a moderate risk, and 30 had a high risk. The median survival of the patients with zero, low, moderate and high risk was 33 months, 21 months, 10 months and 60 days, respectively. The CONUT score was independently associated with mortality at 3 months (HR 1.144; 95% CI 1.062–1.233), 12 months (HR 1.102; 95% CI 1.030–1.179) and 10 years (HR 1.051; 95% CI 1.000–1.103).


Nutritional risk is associated with the short-, medium- and long-term mortality of hospitalized patients with atrial fibrillation.


Atrial fibrillation Nutrition Mortality Cohort study 


Author contributions

We assure that all authors included on a paper fulfill the criteria of authorship. JD-M designed the study. JD-M, and CC-S performed data collection and data analysis. The manuscript was drafted by JD-M, and all authors helped with its revision and gave final approval of this version.



Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical standards

The study was approved by the Ethical Research Committee of Aragon and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

All patients, or its relatives if they were cognitive impaired, gave their informed consent.

Human and animal participant statement

This article does not contain any studies with animals performed by any of the authors.

Ethical statement

The manuscript has not been submitted to more than one journal for simultaneous consideration. The manuscript has not been published previously. There is no. “salami-publishing”. No data have been fabricated or manipulated to support the conclusions. No data, text, or theories by others are presented as if they were the author’s own. Consent to submit has been received explicitly from all co-authors, as well as from the responsible authorities at the institute/organization where the work has been carried out, before the work is submitted.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Internal MedicineHospital Royo VillanovaZaragozaSpain
  2. 2.The Aragon Research Group on Comorbidity and PolypathologyAragon Institute of Health SciencesZaragozaSpain

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