The nutritional risk and short-, medium- and long-term mortality of hospitalized patients with atrial fibrillation
To determine the association between the level of nutritional risk and the mortality of hospitalized patients with atrial fibrillation.
In a prospective cohort study, we included patients hospitalized with atrial fibrillation in an internal medicine department in 2007. We calculated the nutritional risk with the Controlling Nutritional Status (CONUT) score and conducted a 10-year follow-up. To determine the variables associated with mortality in the short (3 months), medium (1 year) and long term (10 years), we constructed a Cox proportional hazards regression model and calculated the Kaplan–Meier survival curves.
The study included 282 patients with a mean (SD) age of 81.2 (7.9) years. The mean CONUT score was 4.7 (2.8) points. Thirty-six patients had zero nutritional risk, 110 had a low risk, 106 had a moderate risk, and 30 had a high risk. The median survival of the patients with zero, low, moderate and high risk was 33 months, 21 months, 10 months and 60 days, respectively. The CONUT score was independently associated with mortality at 3 months (HR 1.144; 95% CI 1.062–1.233), 12 months (HR 1.102; 95% CI 1.030–1.179) and 10 years (HR 1.051; 95% CI 1.000–1.103).
Nutritional risk is associated with the short-, medium- and long-term mortality of hospitalized patients with atrial fibrillation.
KeywordsAtrial fibrillation Nutrition Mortality Cohort study
We assure that all authors included on a paper fulfill the criteria of authorship. JD-M designed the study. JD-M, and CC-S performed data collection and data analysis. The manuscript was drafted by JD-M, and all authors helped with its revision and gave final approval of this version.
Compliance with ethical standards
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
The study was approved by the Ethical Research Committee of Aragon and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
All patients, or its relatives if they were cognitive impaired, gave their informed consent.
Human and animal participant statement
This article does not contain any studies with animals performed by any of the authors.
The manuscript has not been submitted to more than one journal for simultaneous consideration. The manuscript has not been published previously. There is no. “salami-publishing”. No data have been fabricated or manipulated to support the conclusions. No data, text, or theories by others are presented as if they were the author’s own. Consent to submit has been received explicitly from all co-authors, as well as from the responsible authorities at the institute/organization where the work has been carried out, before the work is submitted.
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