Association between serum uric acid levels and coronary artery disease in different age and gender: a cross-sectional study

  • Yujiao Sun
  • Haiyan Zhang
  • Wen Tian
  • Liye Shi
  • Ling Chen
  • Jinyang Li
  • Shijie Zhao
  • Guoxian QiEmail author
Original Article



The association between uric acid (UA) and coronary artery disease (CAD) was controversial. It was still unclear how the UA level changes with age and gender.


To confirm the relationship between the change of UA with age and gender and CAD, especially in elderly people.


8285 individuals were investigated. The changes of UA and hyperuricemia in female and male with age were analyzed. The associations of UA, and hyperuricemia with CAD in different age and sex were assessed.


Individuals were stratified into four groups according to their age: ≤ 39 years; 40–59 years; 60–79 years, and ≥ 80 years. The level of UA and the proportion of hyperuricemia increased significantly with age in female (P < 0.001), but showed a downward trend in male (P < 0.001). After adjusting for confounding factors, hyperuricemia remained an independent risk factor for the incident of CAD in all women (P = 0.029). In ≥ 80 year groups of female, UA and hyperuricemia became independent risk factors for the incident of CAD in the univariate and multivariate logistic regression analyses (all P ≤ 0.001).


The level of UA showed significantly different changes with age in different gender. The relationship between UA and CAD showed differences in different age and sex.


There were significant correlations between UA, hyperuricemia, and CAD only in female, particularly in the ≥ 80 year elderly women, but not in men.


Uric acid (UA) Coronary artery disease (CAD) Age Gender Elderly 



Uric acid


Coronary artery disease


Body mass index




Total cholesterol


High-density lipoprotein cholesterol


Low-density lipoprotein cholesterol


Fasting plasma glucose


Systolic blood pressure


Diastolic blood pressure


Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker


Calcium channel blocker


Hazard ratio


Confidence interval


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Yujiao Sun
    • 1
  • Haiyan Zhang
    • 2
  • Wen Tian
    • 1
  • Liye Shi
    • 1
  • Ling Chen
    • 1
  • Jinyang Li
    • 1
  • Shijie Zhao
    • 1
  • Guoxian Qi
    • 1
    Email author
  1. 1.Department of Geriatric CardiologyThe First Affiliated Hospital of China Medical UniversityShenyangChina
  2. 2.Department of GeriatricsThe First Affiliated Hospital of China Medical UniversityShenyangChina

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