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Low skeletal muscle mass and radiographic osteoarthritis in knee, hip, and lumbar spine: a cross-sectional study

  • Heewon Jeon
  • Shi-Uk Lee
  • Jae-Young Lim
  • Sun Gun Chung
  • Soong Joon Lee
  • Sang Yoon LeeEmail author
Original Article
  • 33 Downloads

Abstract

Background

Although several studies have shown that low skeletal muscle mass is correlated with knee osteoarthritis, no studies have investigated the correlation between skeletal muscle mass and hip and lumbar spine osteoarthritis (OA).

Aim

This study aimed to delineate the relationship between low skeletal muscle mass and radiographic OA (ROA) of the knee, hip, and lumbar spine.

Methods

This is a cross-sectional study using the public data obtained from the Fifth Korean National Health and Nutrition Examination Survey (2010–2011). We included subjects aged ≥ 50 years who completed the surveys (3813 subjects). ROA was assessed by knee, hip, and lumbar spine radiographs and defined as Kellgren/Lawrence (KL) grade of at least 2 in the knee and lumbar spine, whereas KL grade ≥ 1 in the hip. Multivariate logistic regression analyses were performed to evaluate the effects of low skeletal muscle mass on radiographic joint degeneration.

Results

Appendicular skeletal muscle mass (ASM) was higher in subjects with healthy joints than in subjects with knee and lumbar spine ROA (18.9 ± 0.1 kg vs. 17.1 ± 0.2 kg, P < 0.0001 and 18.6 ± 0.1 kg vs. 17.4 ± 0.2 kg, P < 0.0001, respectively), whereas it was higher in those with ROA than in those with healthy hip (17.9 ± 0.1 kg vs. 19.1 ± 0.2 kg P < 0.0001). On multivariate logistic regression analysis, lower skeletal muscle mass independently associated with knee ROA [odds ratio (OR) 1.348; 95% confidence interval (CI) 1.037–1.752]. However, it was inversely associated with lumbar spine ROA (OR 0.786; 95% CI 0.623–0.991).

Conclusion

Low skeletal muscle mass was independently associated with knee ROA alone, whereas it was inversely associated with lumbar spine ROA. These opposite results might originate from measuring the area of ASM.

Keywords

Osteoarthritis Sarcopenia Knee joint Hip joint Lumbar vertebrae Cross-sectional studies 

Notes

Funding

This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (NRF-2017M3A9D8048711). This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

This study was approved by the Korea Centers for Disease Control and Prevention Institutional Review Board and was conducted in compliance with Declaration of Helsinki.

Informed consent

For this type of study, formal consent is not required.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Rehabilitation Medicine, Seoul National University College of MedicineSeoul National University HospitalSeoulRepublic of Korea
  2. 2.Department of Rehabilitation Medicine, Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoulRepublic of Korea
  3. 3.Department of Rehabilitation Medicine, Seoul National University College of MedicineSeoul National University Bundang HospitalSeongnam-siRepublic of Korea
  4. 4.Department of Orthopaedic Surgery, Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoulRepublic of Korea

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