Aging Clinical and Experimental Research

, Volume 31, Issue 7, pp 985–991 | Cite as

Vitamin D deficiency and risk of Helicobacter pylori infection in older adults: a cross-sectional study

  • Deniz Mut SurmeliEmail author
  • Zeki Gokhan Surmeli
  • Remzi Bahsi
  • Tugba Turgut
  • Hande Selvi Oztorun
  • Volkan Atmis
  • Murat Varli
  • Sevgi Aras
Original Article



Vitamin D deficiency is known to cause increased predisposition to various infectious diseases and the addition of vitamin D to antimicrobial treatment may improve treatment responses. However, the relationship between vitamin D and Helicobacter pylori (H. pylori) remains to be determined.


To assess the association between vitamin D deficiency and H. pylori infection.


This cross-sectional study included patients aged 65 and over, who underwent gastroscopy and had gastric biopsy performed between 2010 and 2017. Of the 441 patients, 254 had available 25-hydroxyvitamin D level results and were included in the analyses. Patients were categorized into H. pylori (+) and H. pylori (−) groups, according to histopathological examination results of gastric biopsies. Serum 25(OH) vitamin D levels less than 20 ng/mL were defined as vitamin D deficiency.


Of all patients, 43 were H. pylori (+) and 211 were H. pylori (−). More patients had vitamin D deficiency (< 20 ng/mL) in the H. pylori (+) group than the H. pylori (−) group (86% vs 67.3%, p = 0.014). The proportion of H. pylori (+) patients decreased across increasing quartiles of 25(OH) vitamin D levels (p for trend = 0.010). In multivariable logistic regression analysis, vitamin D deficiency was associated with increased odds of H. pylori infection after adjustment for age, gender, and Charlson Comorbidity Index (OR = 3.02, 95% CI 1.19–7.69, p = 0.020).


Vitamin D deficiency can be associated with increased risk of H. pylori infection. The potential protective effect of vitamin D against H. pylori infection and its possible role in the treatment of H. pylori should be evaluated in prospective trials.


Vitamin D deficiency Helicobacter pylori Aged Gastroscopy 25-Hydroxyvitamin D 2 



This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

This study was approved by institutional ethical board of Ankara University and was conducted in compliance with Declaration of Helsinki.

Informed consent

For this type of study, formal consent is not required.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Department of Geriatrics, Ibni-i Sina HospitalAnkara University School of MedicineAnkaraTurkey
  2. 2.Department of Medical OncologyAnkara Medical Park HospitalAnkaraTurkey
  3. 3.Department of GeriatricsBursa Sevket Yilmaz Training and Research HospitalBursaTurkey

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