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Aging Clinical and Experimental Research

, Volume 31, Issue 2, pp 233–239 | Cite as

Prognostic value of cardiac troponin I assay in hospitalized elderly patients

  • Francesca Attanasio
  • Pamela CarrerEmail author
  • Anna Zurlo
  • Anna Rossi
  • Luciano Babuin
  • Monica Maria Mion
  • Martina Zaninotto
  • Mario Plebani
  • Sabino Iliceto
  • Enzo Manzato
  • Valter Giantin
Original Article

Abstract

Background

Cardiac troponin I (cTnI) has been poorly studied in elderly inpatients.

Aim

This study wanted to assess factors influencing the increase in cTnI and its prognostic value in hospitalized elderly patients.

Methods

354 elderly (mean age of 84.8 ± 6.9 years) patients consecutively admitted in the Geriatrics Division in Padua were tested for cTnI levels assay during the hospital stay. Number of subsequent patient deaths at 6 months and 2 years were registered.

Results

Of the 354 patients, 27 (7.6%) died in hospital; their levels were not significantly higher or more frequently positive on cTnI than those of the remainder of the sample. 71 (20.01%) patients died within 6 months of being discharged, and in-hospital positive cTnI levels emerged as a mortality risk factor in this group [unadjusted HR 1.13 (1.04–1.23); p = 0.004]. At 2 years, a total of 174 patients (49.2%) had died, but in-hospital pathological cTnI levels were not a mortality risk factor in this group.

Discussion

It should be noted that cTnI level was a risk factor for mortality at 6 months but no longer at 2 years after an elderly patient’s hospitalization. This finding may relate to patients’ limited physiological reserves or be driven by the fact that the elderly tend to receive fewer evidence-based treatments, and to be managed more conservatively than younger patients.

Conclusions

In the multidimensional analysis of older patients, troponin I can be used to stratify patients and assess mortality risk at 6 months, but not at 2 years.

Keywords

Aging Coronary heart disease Elderly patients Cardiac troponin I Hospitalization 

Notes

Funding

This study did not receive external funding.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

All procedures performed in this study were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standard.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Francesca Attanasio
    • 1
  • Pamela Carrer
    • 1
    Email author
  • Anna Zurlo
    • 1
  • Anna Rossi
    • 1
  • Luciano Babuin
    • 2
  • Monica Maria Mion
    • 3
  • Martina Zaninotto
    • 3
  • Mario Plebani
    • 3
  • Sabino Iliceto
    • 2
  • Enzo Manzato
    • 1
  • Valter Giantin
    • 1
  1. 1.Geriatrics Division, Department of Medicine (DIMED)University of PadovaPaduaItaly
  2. 2.Department of Cardiac, Thoracic and Vascular SciencesUniversity of PadovaPaduaItaly
  3. 3.Department of Laboratory MedicineUniversity-Hospital of PadovaPaduaItaly

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